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Ion channel drug discovery /
edited by Brian Cox, Martin Gosling.
imprint
Cambridge : Royal Society of Chemistry, [2015]
description
xviii, 366 pages : illustrations (some color) ; 25 cm.
ISBN
1849731861, 9781849731867
format(s)
Book
Holdings
More Details
imprint
Cambridge : Royal Society of Chemistry, [2015]
isbn
1849731861
9781849731867
catalogue key
9966629
 
Includes bibliographical references and index.
A Look Inside
Summaries
Back Cover Copy
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium. This book builds on the platform created by that meeting, covering key themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic and industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.
Back Cover Copy
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium. This book builds on the platform created by that meeting, covering key themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels.Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic and industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.
Back Cover Copy
Ion channel drug discovery is a rapidly evolving field fuelled byrecent, but significant, advances in our understanding of ion channelfunction combined with enabling technologies such as automatedelectrophysiology. The resurgent interest in this target class by bothpharmaceutical and academic scientists was clearly highlighted bythe over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets'symposium. This book builds on the platform created by that meeting,covering key themes including advances in screening technology, ionchannel structure and modelling and up-to-date case histories of thediscovery of modulators of a range of channels, both voltage-gatedand non-voltage-gated channels.Interest and investment in ion channel modulation in both industrialand academic settings continues to grow as new therapeuticopportunities are identified and realised for ion channel modulation.This book provides a reference text by covering a combinationof recent advances in the field, from technological and medicinalchemistry perspectives, as well as providing an introduction to thenew 'ion channel drug discoverer'. The book has contributions fromhighly respected academic and industrial researchers at the cuttingedge of drug discovery and experts in enabling technology. Thiscombination provides a complete picture of the field of interest to awide range of readers.
Description for Bookstore
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium (Feb 2009). This book aims to build on the platform created by this meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels both voltage-gated and non-voltage-gated channels.
Main Description
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.
Main Description
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field.Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.
Table of Contents
Preface
Chanelling drug discovery
Chanome old and new
High throughput screening
Automated electrophysiology
Structure/crystallization/modeling studies
Toxins - does nature do ion channel drug discovery better than us? Structure and function of Sodium Channels, pharmacophores and binding sites
AMPA modulators - a case history
Inhibition of the epithelial sodium channel (ENaC) as a therapeutic approach to respiratory disease
CFTR channel modulation as a therapeutic approach
TRPs are a pain: a case history on TRPV1 antagonist development
The Retigabine story - the M current to therapeutically useful anticonvulsant
Icrac and Orai - a STIMulating channel
hERG past, present and future? Antibodies as ion channel modulators
Summary and the future
Index
Table of Contents provided by Publisher. All Rights Reserved.

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