Catalogue


Environmental toxicology [electronic resource] /
Sigmund F. Zakrzewski.
edition
3rd ed.
imprint
New York : Oxford University Press, 2002.
description
xvii, 334 p. : ill. ; 24 cm.
ISBN
0195148118 (alk. paper), 9780195148114 (alk. paper)
format(s)
Book
More Details
imprint
New York : Oxford University Press, 2002.
isbn
0195148118 (alk. paper)
9780195148114 (alk. paper)
restrictions
Licensed for access by U. of T. users.
general note
Rev. ed. of: Principles of environmental toxicology. 2nd ed. 1997.
catalogue key
9836938
 
Includes bibliographical references and index.
A Look Inside
About the Author
Author Affiliation
Sigmund F. Zakrzewski is Professor Emeritus in the Department of Pharmacology at the State University of New York at Buffalo.
Reviews
Review Quotes
Preface to the First Edition Preface to the Second Edition Preface to the Third Edition 1. Environment: Past and Present 2. Review of Pharmacologic Concepts 3. Metabolism of Xenobiotics 4. Factors that Influence Toxicity 5. Chemical Carcinogenesis and Mutagenesis 6. Endocrine Disrupters 7. Risk Assessment 8. Occupational Toxicology 9. Air Pollution 10. Pollution of the Atmosphere 11. Water and Land Pollution 12. Pollution Control 13. Radioactive Pollution 14. Population, Environment, and Women's Issues 15. Regulatory Policies and International Treaties Appendix. Subjects for Student Seminars Index
This item was reviewed in:
SciTech Book News, June 2002
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Summaries
Long Description
The fundamental principles of environmental toxicology are clearly presented here for university students and professionals in related fields. This book consists of two parts. In the first part basic metabolic, physiological, and pharmacological concepts are used to explain the fate of toxic chemicals in the body, with emphasis on carcinogenesis and mutagenesis. This part also contains a chapter on chemicals disrupting the endocrine system and a chapter on risk assessment and theprecautionary principle. The second section deals with specific environmental problems - air pollution, alteration of the earth's atmosphere, water and land pollution, including sections on wetlands, organic agriculture and genetically modified crops. It also deals with health and environmental effectsof ionized radiation, and the effect of a rapid population growth on the environmental and human welfare. Chapter on pollution control and regulatory policies are also included.
Main Description
The fundamental principles of environmental toxicology are clearly presented here for university students and professionals in related fields. This book consists of two parts. In the first part basic metabolic, physiological, and pharmacological concepts are used to explain the fate of toxicchemicals in the body, with emphasis on carcinogenesis and mutagenesis. This part also contains a chapter on chemicals disrupting the endocrine system and a chapter on risk assessment and the precautionary principle. The second section deals with specific environmental problems - air pollution,alteration of the earth's atmosphere, water and land pollution, including sections on wetlands, organic agriculture and genetically modified crops. It also deals with health and environmental effects of ionized radiation, and the effect of a rapid population growth on the environmental and humanwelfare. Chapter on pollution control and regulatory policies are also included.
Main Description
The fundamental principles of environmental toxicology are clearly presented here for university students and professionals in related fields. This book consists of two parts. In the first part basic metabolic, physiological, and pharmacological concepts are used to explain the fate of toxic chemicals in the body, with emphasis on carcinogenesis and mutagenesis. This part also contains a chapter on chemicals disrupting the endocrine system and a chapter on risk assessment and the precautionary principle. The second section deals with specific environmental problems - air pollution, alteration of the earth's atmosphere, water and land pollution, including sections on wetlands, organic agriculture and genetically modified crops. It also deals with health and environmental effects of ionized radiation, and the effect of a rapid population growth on the environmental and human welfare. Chapter on pollution control and regulatory policies are also included.
Table of Contents
Environment: Past and Presentp. 3
Historical Perspectivep. 3
Present State of the Worldp. 8
The United Nations Conference on Environment and Development: The Earth Summitp. 12
Antienvironmental Movements in the United Statesp. 14
Rio Plus Fivep. 15
The Impact of Global Trade on the Environmentp. 16
Review of Pharmacologic Conceptsp. 19
Dose-Response Relationshipp. 19
The Concept of Receptorsp. 25
Mode of Entry of Toxinsp. 26
Translocation of Xenobioticsp. 30
Metabolism of Xenobioticsp. 39
Phases of Metabolismp. 39
Biotransformationsp. 40
Disposition of Epoxidesp. 43
Conjugationsp. 44
Glutathionep. 47
Induction and Inhibition of P-450 Isozymesp. 49
Activation of Precarcinogensp. 54
Factors that Influence Toxicityp. 61
Selective Toxicityp. 61
Metabolic Pathwaysp. 62
Enzyme Activityp. 62
Xenobiotic-Metabolizing Systemsp. 64
Toxicity Tests in Animalsp. 65
Individual Variations in Response to Xenobioticsp. 69
Chemical Carcinogenesis and Mutagenesisp. 71
Environment and Cancerp. 71
Multistage Development of Cancerp. 73
Types of Carcinogensp. 75
Review of DNA and Chromosomal Structurep. 76
Mutagenesisp. 82
Interaction of Chemicals with DNAp. 85
Xenoestrogens and Breast Cancerp. 92
Carcinogenic Effect of Low-Frequency Electromagnetic Fieldsp. 94
DNA Repair Mechanismp. 94
Oncogenes and Tumor Supressor Genesp. 95
Endocrine Disruptersp. 98
Historical Perspectivesp. 98
Hormonal Imbalancep. 99
Properties of Endocrine Disruptersp. 100
Environmental and Health Impact of Endocrine Disruptersp. 102
Risk Assessmentp. 108
Hazard Assessmentp. 108
Dose-Response Assessmentp. 114
Exposure Assessmentp. 117
Risk Characterizationp. 118
Critique of Risk Assessmentp. 119
Risk Assessment of Endocrine Disruptersp. 120
Ecological Risk Assessmentp. 121
The Principle of Precautionary Actionp. 121
Occupational Toxicologyp. 123
Threshold Limit Values and Biological Exposure Indicesp. 123
Respiratory Toxicityp. 124
Irritation of Airways and Edemap. 125
Pulmonary Fibrosisp. 127
Pulmonary Neoplasiap. 129
Allergic Responsesp. 129
Nephrotoxinsp. 133
Liver Damagep. 138
Other Toxic Responsesp. 142
Air Pollutionp. 145
Pollutant Cyclesp. 145
Urban Pollutants: Their Sources and Biological Effectsp. 145
Trends and Present Status of Air Qualityp. 156
Pollution by Motor Vehiclesp. 160
Pollution by Industrial Chemicalsp. 162
Pollution by Incineratorsp. 166
Tall Stacks and Their Role in Transport of Pollutantsp. 168
Indoor Air Pollutionp. 168
Pollution of the Atmospherep. 173
The Earth's Atmospherep. 173
Formation and Sustenance of Stratospheric Ozonep. 176
Depletion of Stratospheric Ozonep. 177
Emission of CO[subscript 2] and Models of Climatic Changesp. 183
Current Developmentsp. 190
The Effects of Atmospheric Changes on Human Healthp. 195
Water and Land Pollutionp. 199
Freshwater Reservesp. 199
Nitrogen Overloadp. 200
Transport of Water Pollutantsp. 201
Urban Pollutantsp. 201
Lead Pollutionp. 204
Soil Erosionp. 205
Nutrients and Pesticidesp. 207
Alternative Agriculturep. 215
Genetically Modified Cropsp. 215
Wetlands and Estuariesp. 217
Industrial Pollutantsp. 220
Pollution of Groundwaterp. 231
Airborne Water and Land Pollutionp. 233
Pollution Controlp. 241
Clean-Coal Technologyp. 241
Control of Mobile-Source Emissionp. 245
Control of Nitrogen Oxidesp. 249
Energy Conservationp. 250
Wastewater Treatmentp. 252
Waste Disposal and Recyclingp. 255
Hazardous Wastep. 263
Radioactive Pollutionp. 267
Ionizing Radiationp. 267
Measurement of Radioactivityp. 269
Sources of Radiationp. 270
Health and Biological Effects of Radiationp. 272
Nuclear Energyp. 275
Population, Environment, and Women's Issuesp. 287
Present Trends in Population Growthp. 287
Effect of Overpopulation on the Environmentp. 293
Overpopulation, Urban Sprawl, and Public Healthp. 296
International Cooperation on Population Issuesp. 298
Regulatory Policies and International Treatiesp. 302
The National Environmental Policy Actp. 302
Environmental Regulatory Frameworkp. 303
EPA and Its Responsibilitiesp. 305
OSHA and Its Responsibilitiesp. 316
Miscellaneous Environmental Acts and Treatiesp. 318
Subjects for Student Seminarsp. 321
Indexp. 322
Table of Contents provided by Rittenhouse. All Rights Reserved.

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