Catalogue


Non-clinical vascular infusion technology /
Owen P. Green and Guy Healing.
imprint
Boca Raton : CRC Press/Taylor & Francis, [2014-]
description
v. <1- >
ISBN
1439874492 (hardcover : alk. paper), 9781439874493 (hardcover : alk. paper)
format(s)
Book
Holdings
More Details
imprint
Boca Raton : CRC Press/Taylor & Francis, [2014-]
isbn
1439874492 (hardcover : alk. paper)
9781439874493 (hardcover : alk. paper)
contents note
Volume 1. The science -- volume 2. The techniques.
abstract
"Preface There are many pharmaceuticals on the market or undergoing clinical trials that require intravenous infusion, for either short or longer periods, intermittently or continuously, and so this book should be of interest to those in pharmaceutical research and development, as well as in other research areas. These applications include chemotherapy and the treatment of various diseases such as HIV, hepatitis C, and cardiovascular disease, as well as during and following problematical surgical procedures. It is a regulatory and ethical requirement that these pharmaceuticals first be tested on both rodents and non-rodents by the clinical route, and so the range of pre-clinical experimental models is covered. The technique of prolonged intravenous delivery in conscious, free-moving animal models has also broadened the opportunities to study and evaluate the safety and efficacy of those products that have limiting biological or chemical properties such as half-life and formulation issues. In 2000 the first book covering pre-clinical infusion techniques was published by Taylor & Francis (Handbook of Pre-Clinical Continuous Intravenous Infusion, Healing and Smith, editors) and this has become the singular reference source for this technology up to the present time. However, it is now recognised that a number of the techniques have been refined since that time, and also that new and improved equipment has been developed"--Provided by publisher.
catalogue key
9087205
 
Includes bibliographical references and index.
A Look Inside
Reviews
Review Quotes
"Good science and good welfare go hand in hand. Innovative science and technology can be used to improve animal welfare. Equally, the 3Rs (replacement, refinement and reduction of animals in research) can provide fresh insight and novel approaches to advance science. By sharing data, knowledge and experience on the science behind infusion models and the refinement of the techniques used, there is the potential to have a significant impact on the 3Rs. Owen Green and Guy Healing have shown the importance of the 3Rs in infusion technology at international meetings and in producing this book. The book will enhance uptake of the latest science behind vascular delivery systems to get better data and help influence decisions around the most appropriate model. It will also contribute to preventing repetition of method development and optimising experiments to answer specific scientific questions with the least impact on animals. As in other areas of science, the field of infusion technology is constantly evolving. This edition of Non-Clinical Vascular Infusion Technology reviews current developments in the field that will support scientists in putting the 3Rs into practice." --From the Foreword by Kathryn Chapman, Head of Innovation and Translation, the National Centre for the Replacement, Refinement and Reduction of Animals in Research
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Summaries
Bowker Data Service Summary
Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication.
Main Description
Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication. Non-Clinical Vascular Infusion Technology, Volume I: The Science covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. The book addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus. This volume, along with Volume II: The Techniques , provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features Identifies and shares best practices for non-clinical vascular infusion Presents modern practices and procedures in line with up-to-date equipment development Offers recommendations for in-life assessments in order to monitor the success or problems with the vascular infusion delivery Makes comparisons with human data in many areas
Main Description
With the evolution of vascular infusion technology, its use in the preclinical safety assessment of pharmaceuticals has become increasingly widespread. Hence, a need has developed for a single source on the scientific principles behind this technology. A logical companion to the new edition of The Techniques of Non-Clinical Vascular Infusion Technology, this book brings together current knowledge and underlying practices from around the world to help refine the procedures and enhance the global understanding of infusion technology.

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