Catalogue


Use of left ventricular assist devices as destination therapy in end-stage congestive heart failure [electronic resource] : a systematic review /
prepared for Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by Evidence-based Synthesis Program (ESP) Center, Minneapolis VA Medical Center, Timothy J. Wilt ; investigators, principal investigators, Thomas S. Rector, Brent C. Taylor, research Associates, Nancy Greer, Indulis Rutks.
imprint
[Washington, D.C.] : Dept. of Veterans Affairs, Health Services Research & Development Service, [2012]
description
1 online resource (1 PDF file (iii, 41 p.)) : ill.
format(s)
Book
Holdings
More Details
imprint
[Washington, D.C.] : Dept. of Veterans Affairs, Health Services Research & Development Service, [2012]
restrictions
Licensed for access by U. of T. users.
general note
"May 2012."
abstract
Heart failure is defined as reduced ability of the heart to pump blood and maintain normal bodily function. Heart transplantation is currently the preferred treatment for end-stage heart failure but the supply of donor hearts is insufficient to meet the need and many patients are not eligible for transplantation due to age or comorbid conditions. Implantable mechanical pumps can assist the circulation of blood by the ventricles. Left ventricular assist devices (LVADs) have been approved by the U.S. Food and Drug Administration (FDA) for use in patients awaiting transplant (a bridge to transplant) and as a last resort in patients with refractory heart failure who are not eligible for a heart transplant (destination therapy). In January 2010, the first newer generation, rotary continuous flow ventricular assist device (HeartMate II) was approved by the FDA for destination therapy. Eligibility criteria are essentially the same as those used to select patients for the pivotal clinical trial that included patients with shortness of breath and/or fatigue at rest or during minimal exertion despite treatment with optimal therapy for heart failure associated with a low ejection fraction (< 25%) who were not candidates for heart transplantation due to their age or co-morbid conditions. The purpose of this report is to review the scientific evidence for use of the current generation of left ventricular assist devices as destination therapy.
catalogue key
9070213
 
Includes bibliographical references.

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