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Crucible of science : the story of the Cori laboratory /
John H. Exton.
imprint
Oxford ; New York : Oxford University Press, [2013], c2013
description
xvi, 226 p.
ISBN
0199861072 (hardcover : alk. paper), 9780199861071 (hardcover : alk. paper)
format(s)
Book
Holdings
More Details
imprint
Oxford ; New York : Oxford University Press, [2013], c2013
isbn
0199861072 (hardcover : alk. paper)
9780199861071 (hardcover : alk. paper)
catalogue key
8892014
 
Includes bibliographical references and index.
A Look Inside
Summaries
Bowker Data Service Summary
This title examines the careers of Carl and Gerty Cori, and the other eminent scientists who trained in their laboratory.
Long Description
"Crucible of Science" is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escape deteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to winthe Nobel Prize, the laboratory they established at the University has since produced some of the most outstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental inestablishing the then new science of Biochemistry in the U.S. They applied chemical approaches to elucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme catalysts that carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were above question. This book examines the careers of both Coris and the other eminent scientists who trained in their laboratory. It notes the Coris' acceptance of women, Jews, and scientists from all over the world, unique during this time period. It analyzes those reasons why the laboratory was so successful in attracting the best trainees and producing premier scientists. Intended for scientists, science historians, and anyone interested in the history of science, "Crucible of Science" is a unique presentationof remarkable careers and personalities, examined within the context of the Coris' laboratory.
Main Description
Crucible of Science is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escapedeteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to win the Nobel Prize, the laboratory they established at the University has since produced some of the mostoutstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental in establishing the then new science of Biochemistry in the U.S. They applied chemical approaches toelucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme catalysts that carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were abovequestion. This book examines the careers of both Coris and the other eminent scientists who trained in their laboratory. It notes the Coris' acceptance of women, Jews, and scientists from all over the world, unique during this time period. It analyzes those reasons why the laboratory was so successful inattracting the best trainees and producing premier scientists. Intended for scientists, science historians, and anyone interested in the history of science, Crucible of Science is a unique presentation of remarkable careers and personalities, examined within the context of the Coris'laboratory.
Table of Contents
Acknowledgmentsp. ix
Introductionp. xi
Carl and Getty Cori: Early Lifep. 1
Sidney Colowick: Their First Graduate Studentp. 16
Herman Kalckar: The Great Danep. 21
Severo Ochoa: Spanish Geniusp. 29
Move to Enzymology and Work of Arda Greenp. 39
Luis Leloir: One of Argentina's Greatest Scientistsp. 45
Earl Sutherland: Master of Intuitionp. 53
Coris' Move to the Department of Biological Chemistry: Award of Nobel Prizes and Career of Tom Corip. 67
Sidney Velick: Modest Enzymologistp. 73
Victor Najjar: Pediatrician and Immunochemistp. 78
Edwin Krebs: Accidental Biochemistp. 82
Mildred Cohn: Against All Oddsp. 91
Christian de Duve: Belgian with Savoir Fairep. 100
Arthur Kornberg: A Giant of Biochemistryp. 112
Hormone Effects on Muscle Carbohydrate Metabolismp. 123
Charles Park: Aristocratic Physiologistp. 127
Jane Harting Park: Enthusiast for Sciencep. 139
Gerty Cori's Work on Glycogen Structure and Glycogen Storage Diseasesp. 145
Joseph Lamer: Focus on Glycogen Synthasep. 149
Contributions of Barbara and David Brownp. 161
William Daughaday: All About Growthp. 161
Robert Crane: A Decade with Carl Corip. 171
Alberto Sols: Spanish Enzymologistp. 176
Luis Glaser: The Complexity of Carbohydratesp. 181
Ernst Helmreich: Jovial Bavarianp. 189
Carl Frieden: Enzyme Kineticistp. 196
David Kipnis: Focus on Diabetesp. 201
William Danforth: Academic Leaderp. 206
The Influence of the Coris on Washington University and Carl Cori's Research at Bostonp. 210
The Heritage of the Corisp. 214
Indexp. 221
Table of Contents provided by Ingram. All Rights Reserved.

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