Catalogue


Contemporary aspects of biomedical research [electronic resource] : drug discovery /
S.J. Enna, Michael Williams.
imprint
San Diego : Academic Press, 2009.
description
xii, 501 p. : ill.
ISBN
9780123786425
format(s)
Book
More Details
added author
imprint
San Diego : Academic Press, 2009.
isbn
9780123786425
restrictions
Licensed for access by U. of T. users.
catalogue key
8671560
 
Includes bibliographical references and index.
A Look Inside
Reviews
Review Quotes
PRAISE FOR THE SERIES "...recommended not only to pharmacologists but also to all those in related disciplines"--NATURE "The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated."--H.E. Kaufmann in CHEMOTHERAPY "Superb reading material."--JOURNAL OF PHARMACEUTICAL SCIENCES
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Summaries
Main Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Articles written by leading investigators in the field Informs and updates on all the latest developments
Table of Contents
Contributorsp. ix
Prefacep. xi
Defining the Role of Pharmacology in the Emerging World of Translational Research
Introductionp. 2
Historical Perspective of Pharmacologyp. 4
Initiatives to Improve Drug Discovery Productivityp. 7
Pharmacology as an Enabling Science in Translational Researchp. 16
Conclusionp. 21
Referencesp. 22
Anti-Inflammatory Agents as Cancer Therapeutics
Introductionp. 32
Blocking Chemokines and or Chemokine Receptors as Approaches to Cancer Therapyp. 37
Evidence that NSAIDs Protect Against Cancerp. 38
Inhibition of (Prostanoid Receptors for Cancer Preventionp. 41
LOX Cascadesp. 43
Nitric Oxide-Releasing NSAIDs (NO-NSAIDS and NONO- NSAIDs)p. 48
Hydrogen Sulfide-Releasing NSAIDsp. 61
Natural Products for Cancer Preventionp. 67
Conclusionp. 70
Referencesp. 71
The Development and Pharmacology of Proteasome Inhibitors for the Management and Treatment of Cancer
Introductionp. 92
Molecular and Biological Roles of the Proteasome Complex in Cellular Homeostasis and Diseasep. 93
Historical Perspective of Proteasome Inhibitors in Development: Chemistry and Primary Mechanisms of Actionp. 99
Preclinical In Vitro and In Vivo Pharmacology of Proteasome Inhibitors in Hematological and Non-hematological Cancersp. 103
Clinical Studies with Proteasome Inhibitorsp. 113
Clinical Studies with "Next-Generation" Proteasome Inhibitorsp. 122
Conclusionp. 125
Referencesp. 126
Subtype-Selective GABAA Receptor Modulation Yields a Novel Pharmacological Profile: The Design and Development of TPA023
Introductionp. 138
Identification of TPA023p. 146
Preclinical Features of TPA023p. 149
Preclinical Metabolism and Pharmacokinetics of TPA023p. 159
Human Studiesp. 162
Additional Anxioselective and Other GABAA Receptor Modulatorsp. 173
Conclusionp. 177
Referencesp. 178
New Approaches for the Treatment of Sleep Disorders
Introductionp. 188
Narcolepsyp. 189
Obstructive Sleep Apneap. 197
Insomniap. 205
Restless Leg Syndromep. 215
Conclusionp. 223
Referencesp. 224
Current and Emerging Strategies for Treating Dysiipidemia and Macrovascular Disease
Introductionp. 238
Mechanisms of Actionp. 241
Conclusionp. 247
Referencesp. 248
Discovery of Drugs to Treat Cocaine Dependence: Behavioral and Neurochemical Effects of Atypical Dopamine Transport Inhibitors
Introductionp. 254
Behavioral Studiesp. 258
Pharmacokinetic Studiesp. 271
Studies of In Vivo Binding of BZT Analogs at the DAT and Relationship with Behavioral and Neurochemical Effectsp. 271
Influence of Off-Target Actions of BZT Analogsp. 274
Studies of DAT Structure as Related to Its Functionp. 279
Conclusionp. 282
Referencesp. 283
Novel Strategies and Targets for the Management of Hypertension
Introductionp. 292
Physiological Regulation of Blood Pressurep. 309
Experimental Models of Hypertensionp. 318
Novel Targets/Agents for Therapeutic Management of Hypertensionp. 324
Conclusionp. 334
Referencesp. 335
New Approaches to the Pharmacological Management of Major Depressive Disorder
Introductionp. 348
Mood Disordersp. 349
Antidepressantsp. 349
New Targets in Discovery and Developmentp. 352
Glutaraate Modulationp. 363
Conclusionp. 369
Referencesp. 370
Preclinical Behavioral Models for Predicting Antipsychotic Activity
Introductionp. 382
Procedures for Evaluating Positive Symptomsp. 385
Procedures for Evaluating Negative Symptomsp. 390
Procedures for Evaluating Cognitive Deficitsp. 392
Procedures for Evaluating EPSp. 400
Conclusionp. 406
Referencesp. 409
New Developments in the Therapy of Pulmonary Fibrosis
Introductionp. 420
Fibrosis and Fibrogenesisp. 420
Fibrotic Diseasesp. 422
Search for Antifibrotic Drugsp. 428
Pirfenidonep. 440
Gene Therapyp. 445
Conclusionp. 446
Referencesp. 448
Indexp. 465
Contents of Previous Volumesp. 483
Table of Contents provided by Ingram. All Rights Reserved.

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