Catalogue


Ocular drug delivery systems : barriers and application of nanoparticulate systems /
edited by Deepak Thassu and Gerald J. Chader.
imprint
Boca Raton : CRC Press/Taylor & Francis, c2013.
description
xv, 447 p., [10] p. of plates : ill. (some col.) ; 24 cm.
ISBN
1439848009 (hardcover : alk. paper), 9781439848005 (hardcover : alk. paper)
format(s)
Book
Holdings
More Details
imprint
Boca Raton : CRC Press/Taylor & Francis, c2013.
isbn
1439848009 (hardcover : alk. paper)
9781439848005 (hardcover : alk. paper)
contents note
Nanoparticulate-based therapeutics : an overview / Deepak Thassu, Kris Holt, and Gerald J. Chader -- Eye anatomy, physiology and ocular barriers : basic considerations for drug delivery / Gerald J. Chader and Deepak Thassu -- Animal models to evaluate nanoparticulate drug delivery systems / Vinson M. Wang, Jingsheng Tuo and Chi-Chao Chan -- Computer modeling for ocular drug delivery / Paul J. Missel -- Challenges in the development of nanotechnology-based ophthalmic systems / Banu S. Zolnik, Sherizaq Baksh and Nakissa Sadrieh -- Blood-retinal barrier : the fundamentals / Rosa Fernandes, Andreia Goncalves and Jose Cunha-Vaz -- Barriers to transscleral drug delivery to the retina / Alexandra Almazan ... [et al.] -- Drug delivery to the vitreous humor / Francine Behar-Cohen -- Transscleral and suprachoroidal drug delivery / Damian E. Berezovsky and Henry Edelhauser -- Protein drug delivery to retina and choroid / Hogwen M. Rivers and Patrick M. Hughes -- Transscleral drug delivery to the posterior segment of the eye / Bernard F. Godley ... [et al.] -- Drug delivery to the suprachoroidal space / Sung Won Cho and Timothy Olsen -- Use of nanoparticles in the treatment of age-related macular degeneration, glaucoma and other degenerative retinal diseases / Marco A. Zarbin ... [et al.] -- Drug molecule characteristics, drug delivery strategies and their impact on ophthalmic drug delivery to anterior vs. posterior segments / Kay D. Rittenhouse -- Surface modulation of nanoparticles / Deepak Thassu and Kris Holt -- Ophthalmic drug inserts / Kay Rittenhouse and Deepak Thassu -- Nanoparticles for the treatment of retinal diseases / Amin Famili and Uday Kompella -- Gene-based medicine for ocular diseases -- Shannon M. Conley and Muna I. Naash -- Stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate for treatment of intraocular inflammation / Tsutomu Sakai, Tsutomu Ishihara and Megumu Higaki -- Nanotechnology-guided imaging of retinal vascular disease / Joshua R. Trantum and Ashwath Jayagopal -- Photoresponsive polymers for ocular drug delivery / Laura A. Wells and Heather Sheardown -- Nanosuspensions in ocular drug delivery systems / Himanshu Bhattacharjee and Sonia Bedi.
catalogue key
8653073
 
Includes bibliographical references and index.
A Look Inside
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This item was reviewed in:
Reference & Research Book News, December 2012
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Summaries
Main Description
Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems
Main Description
Written for academic and industrial researchers in the field of ophthalmology, this book presents research on the development of currently marketed devices and recent trends for the future delivery of drugs topically to the posterior eye. As the only book to cover drug delivery barriers and the application of nano-medicines to the eye, it includes chapters on ocular physiology and the application of nanoparticles-based delivery systems to enhance drug efficacy. Contributors include leading eye researchers, surgeons, and pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis.
Main Description
Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet, without good drug delivery systems, these drugs are less effective than they could be, possibly even ineffective or could cause serious side effects. Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems presents research on the development of currently marketed devices and recent trends in the topical delivery of drugs to the posterior of the eye. With contributions from leading pharmaceutical researchers and industry experts, eye researchers, surgeons, pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis, the book not only presents the state of the art in the use of nanoparticles in ocular drug delivery systems but sets the stage for future developments. This volume gives both a current evaluation and a future roadmap for developments in ocular drug delivery. The subjects range from biological needs to material challenges and finally to clinical applications for improving drug delivery for conditions where treatments already exist and for unmet needs where effective drugs may be available but yet need a safe, efficient, and efficacious delivery vehicle.
Bowker Data Service Summary
Written for academic and industrial researchers in the field of ophthalmology, this book presents research on the development of currently marketed devices and recent trends for the future delivery of drugs topically to the posterior eye.
Main Description
Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet, without good drug delivery systems, these drugs are less effective than they could be, possibly even ineffective or could cause serious side effects. Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems presents research on the development of currently marketed devices and recent trends for the future delivery of drugs to the posterior eye. With contributions from leading pharmaceutical researchers and industry experts, eye researchers, surgeons, pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis, the book not only presents the state of the art in the use of nanoparticles in ocular drug delivery systems but sets the stage for future developments. This volume gives both a current evaluation and a future roadmap for developments in ocular drug delivery. The subjects range from biological needs to material challenges and finally to clinical applications for improving drug delivery for conditions where treatments already exist and for unmet needs where effective drugs may be available but yet need a safe, efficient, and efficacious delivery vehicle.
Table of Contents
Prefacep. ix
Editorsp. xi
Contributorsp. xiii
Basic Considerations
Nanoparticle-Based Therapeutics: An Overviewp. 3
Eye Anatomy, Physiology, and Ocular Barriers: Basic Considerations for Drug Deliveryp. 17
Animal Models to Evaluate Ocular Nanoparticular Drug Delivery Systemsp. 41
Computer Modeling for Ocular Drug Deliveryp. 59
Considerations for Development of Ophthalmic Nanotechnology-Based Drugsp. 95
Ocular Barriers
Blood-Retinal Barrier: The Fundamentalsp. 111
Barriers to Transscleral Drug Delivery to the Retinap. 133
Ocular Compartment Drug Delivery
Drug Delivery to the Vitreous Humorp. 159
Transscleral and Suprachoroidal Drug Deliveryp. 179
Protein Drug Delivery to Retina and Choroidp. 191
Transscleral Drug Delivery to the Posterior Segment of the Eyep. 215
Drug Delivery to the Suprachoroidal Spacep. 235
Use of Nanoparticles in the Treatment of Age-Related Macular Degeneration, Glaucoma, and Other Degenerative Retinal Diseasesp. 259
Drug Delivery Systems
Drug Molecule Characteristics and Their Impact on Anterior versus Posterior Segment Drug Delivery Strategiesp. 285
Surface Modulation of Nanoparticlesp. 301
Nanoparticles for the Treatment of Retinal Diseasesp. 307
Gene-Based Medicine for Ocular Diseasesp. 327
Stealth-Type Polymeric Nanoparticles with Encapsulated Betamethasone Phosphate for Treatment of Intraocular Inflammationp. 355
Technology and Materials Development
Nanotechnology-Guided Imaging of Retinal Vascular Diseasep. 365
Photoresponsive Polymers for Ocular Drug Deliveryp. 383
Nanosuspensions in Ocular Drug Delivery Systemsp. 401
Indexp. 433
Table of Contents provided by Ingram. All Rights Reserved.

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