Catalogue


ADME-enabling technologies for drug design and development [electronic resource] /
edited by Donglu Zhang, Sekhar Surapaneni.
imprint
Hoboken, N.J. : John Wiley & Sons, Inc., c2012.
description
xxix, 591 p. : ill. ; 29 cm.
ISBN
0470542780 (cloth), 9780470542781 (cloth)
format(s)
Book
More Details
imprint
Hoboken, N.J. : John Wiley & Sons, Inc., c2012.
isbn
0470542780 (cloth)
9780470542781 (cloth)
restrictions
Licensed for access by U. of T. users.
catalogue key
8540034
 
Includes bibliographical references and index.
A Look Inside
Reviews
Review Quotes
Review copy sent on 18.6.12 to BTS Newsletter review
"This book fills time needs of ADME researchers and provides a fine reference book for scientists engaged in the areas of medicinal chemistry, pharmaceutics, bioanalytical sciences, pharmacology and toxicology in academia and pharmaceutical industry." ( British Toxicology Society , 1 July 2013)
To find out how to look for other reviews, please see our guides to finding book reviews in the Sciences or Social Sciences and Humanities.
Summaries
Bowker Data Service Summary
This text covers the state-of-the-art and cutting-edge technologies in an integrated fashion for applications in ADME studies of small molecular drugs. Each chapter provides descriptions of the technologies, application scope and limitations, optimal conditions for intended results, and much more.
Long Description
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Main Description
This book comprehensively covers the state-of-art and cutting-edge technologies in an integrated fashion for applications in ADME studies of small molecular drugs. Each chapter provides descriptions of the technologies, application scope and limitations, optimal conditions for intended results, protocols, case studies, and future developments. By concisely describing these technologies, the book provides a useful tool for drug metabolism scientists and as a reference for scientists in the fields of pharmacology, medicinal chemistry, pharmaceutics, toxicology, bioanalytical science in academia and industry.
Main Description
This book comprehensively covers the state-of-the-art and cutting-edge technologies in an integrated fashion for applications in ADME studies of small molecular drugs. Each chapter provides descriptions of the technologies, application scope and limitations, optimal conditions for intended results, protocols, case studies, and future developments. By concisely describing these technologies, the book provides a useful tool for drug metabolism scientists and as a reference for scientists in the fields of pharmacology, medicinal chemistry, pharmaceutics, toxicology, bioanalytical science in academia and industry.
Table of Contents
Preface
Forward
ADME: Overview and Current Topics
Regulatory drug disposition and NDA package including MIST
Optimal ADME properties of a clinical candidate and investigational new drug (IND) package
Drug transporters in Drug interactions and disposition
Pharmacological and toxicological activity of drug metabolites
Improving the pharmaceutical properties of biologics in drug discovery: Unique challenges and enabling solutions
Clinical dose estimation using pharmacokinetic/pharmacodynamic simulation and modeling
Pharmacogenomics and individualized medicines
Overview of pharmacokinetic and drug metabolism with applications to drug discovery and development in China
ADMET Systems and Methods
Technical challenges and recent advances of implementing comprehensive ADMET tools in drug discovery and development
Permeability and Transporter models in drug discovery and development
Methods to assess blood brain penetration in drug discovery
Protein binding determination and application
Reaction phenotyping
Fast and reliable CYP inhibition assays
Tools and strategies for the assessment of enzyme induction in drug discovery and development
Animal models for studying metabolizing enzymes and transporters
Milk excretion and placenta studies
Bile collection from animals and humans
Analytical Technologies
Current technology and limitation of LC/MS
Applications of accurate mass in metabolite identification
Applications of accelerated mass spectrometry
Radioactivity profiling
Small scale NMR analysis for metabolite identification
Super-critical fluid chromatography for compound isolation
Chromatographic separation methods
Mass spectrometric imaging for drug distribution in tissues
QWBA applications in drug distribution
New and Related Technologies
Genetically modified mouse models in ADME studies
Pluripotent stem cells have an important role in human drug development
Radiosynthesis for ADME studies
Formulation development for preclinical in-vivo studies
In vitro testing of cardiovascular toxicity
Target engagement for PK-PD modeling and translational biomarkers
Applications of siRNA technologies in drug transporters and drug metabolizing enzymes
Table of Contents provided by Publisher. All Rights Reserved.

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