Catalogue


Gene transfer and the ethics of first-in-human research [electronic resource] : lost in translation /
Jonathan Kimmelman.
imprint
Cambridge, UK ; New York : Cambridge University Press, 2010.
description
xi, 205 p. : ill. ; 24 cm.
ISBN
0521690846 (pbk. : alk. paper), 9780521690843 (pbk. : alk. paper)
format(s)
Book
More Details
imprint
Cambridge, UK ; New York : Cambridge University Press, 2010.
isbn
0521690846 (pbk. : alk. paper)
9780521690843 (pbk. : alk. paper)
restrictions
Licensed for access by U. of T. users.
contents note
Introduction: gene transfer lost in translation -- What is gene transfer? -- Safety, values, and legitimacy: the protean nature of risk in translational trials -- Taming uncertainty: risk and gene-transfer clinical research -- Succor or suckers? Benefit, risk, and the therapeutic misconception -- Looking backward: a model value for translational trials -- The chasm: the ethics of initiating first-in-human clinical trials -- Tropic of cancers: gene transfer in resource-poor settings -- Great expectations and hard times: expectation management in gene transfer -- Something in the sight adjusts itself: conclusions.
abstract
"Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions"--Provided by publisher.
catalogue key
8363432
 
Includes bibliographical references and index.
A Look Inside
About the Author
Author Affiliation
Jonathan Kimmelman is Assistant Professor, Biomedical Ethics unit/social studies of Medicine, McGill University, Montreal, Quebec, Canada.
Reviews
This item was reviewed in:
Reference & Research Book News, April 2011
To find out how to look for other reviews, please see our guides to finding book reviews in the Sciences or Social Sciences and Humanities.
Summaries
Description for Bookstore
This book examines the ethical and policy dimensions of testing interventions in human beings for the first time. It discusses numerous distinctive ethical challenges encountered in attempting to translate preclinical findings into clinical applications. It is relevant to ethicists, legal practitioners, policy makers, clinical researchers and geneticists.
Main Description
Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions.
Table of Contents
Acknowledgmentsp. viii
List of abbreviationsp. x
Introduction: gene transfer lost in translationp. 1
What is gene transfer?p. 8
Safety, values, and legitimacy: the protean nature of risk in translational trialsp. 31
Taming uncertainty: risk and gene-transfer clinical researchp. 51
Succor or suckers? Benefit, risk, and the therapeutic misconceptionp. 72
Looking backward: a model of value for translational trialsp. 89
The chasm: the ethics of initiating first-in-human clinical trialsp. 110
Tropic of cancers: gene transfer in resource-poor settingsp. 132
Great Expectations and Hard Times: expectation management in gene transferp. 153
Something in the sight adjusts itself: conclusionsp. 178
Epiloguep. 192
Indexp. 193
Table of Contents provided by Ingram. All Rights Reserved.

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