Catalogue


Proteomics in drug research [electronic resource] /
edited by Michael Hamacher ... [et al.].
imprint
Weinheim : Wiley-VCH, c2006.
description
xxi, 362 p. : ill. ; 25 cm.
ISBN
3527312269, 9783527312269
format(s)
Book
Subjects
More Details
added author
imprint
Weinheim : Wiley-VCH, c2006.
isbn
3527312269
9783527312269
restrictions
Licensed for access by U. of T. users.
catalogue key
8040617
 
Includes bibliographical references and index.
A Look Inside
Reviews
Review Quotes
"The scope is broad, encompassing administrative, scientific, and marketing components....this book can certainly find a place in the library of any organization that makes use of proteomics." ( Journal of Medicinal Chemistry , December 14, 2006)
To find out how to look for other reviews, please see our guides to finding book reviews in the Sciences or Social Sciences and Humanities.
Summaries
Back Cover Copy
By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs. From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Back Cover Copy
By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs. From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimers disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Back Cover Copy
By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs. From skillful handling of the wide range of technologies to successful applications in drug discovery-this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Back Cover Copy
By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs.From skillful handling of the wide range of technologies to successful applications in drug discovery-this handbook has all the information professional proteomics users need.Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Long Description
By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs. From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer2s disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Main Description
From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Main Description
From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimers disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Main Description
From skillful handling of the wide range of technologies to successful applications in drug discovery-this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Main Description
From skillful handling of the wide range of technologies to successful applications in drug discovery-this handbook has all the information professional proteomics users need.Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Table of Contents
A Personal Foreword
Preface
List of Contributors
Introduction
Administrative Optimization of Proteomics Networks for Drug Development
Introduction
Tasks and Aims of Administration
Networking
Evaluation of Biomarkers
A Network for Proteomics in Drug Development
Realization of Administrative Networking: the Brain Proteome Projects
References
Proteomic Data Standardization, Deposition and Exchange
Introduction
Protein Analysis Tools
Data Storage and Retrieval
The Proteome Standards Initiative
General Proteomics Standards (GPS)
Mass Spectrometry
Molecular Interactions
Summary
References
Proteomic Technologies
Difference Gel Electrophoresis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical Research
Introduction
Difference Gel Electrophoresis: Next Generation of Protein Detection in 2-DE.References
Biological Mass Spectrometry: Basics and Drug Discovery Related Approaches
Introduction
Ionization Principles
Mass Spectrometric Instrumentation
Protein Identification Strategies
Quantitative Mass Spectrometry for Comparative and Functional Proteomics
Metabolic Labeling Approaches
Chemical Labeling Approaches
Quantitative MS for Deciphering Protein-Protein Interactions
Conclusions
References
Multidimensional Column Liquid Chromatography (LC) in Proteomics - Where Are We Now?
Introduction
Why Do We Need MD-LC/MS Methods?
Basic Aspects of Developing a MD-LC/MS Method
Applications of MD-LC Separation in Proteomics - a Brief Survey
Sample Clean-Up: Ways to Overcome the "Bottleneck" in Proteome Analysis
Summary
References
Peptidomics Technologies and Applications in Drug Research
Introduction
Peptides in Drug Research
Development of Peptidomics Technologies
Applications of Differential Display Peptidomics
Outlook
References
Protein Biochips in the Proteomic Field
Introduction
Technological Aspects
Applications of Protein Biochips
Contribution to Pharmaceutical Research and Development
References
Current Developments for the In Vitro Characterization of Protein Interactions
Introduction
The Model System: cAMP-Dependent Protein Kinase
Real-time Monitoring of Interactions Using SPR Biosensors
ITC in Drug Design
Fluorescence Polarization, a Tool for High-Throughput Screening
AlphaScr
Table of Contents provided by Publisher. All Rights Reserved.

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