Catalogue


Proteomics for biological discovery [electronic resource] /
[edited by] Timothy D. Veenstra, John R. Yates.
imprint
Hoboken, N.J. : Wiley-Liss, c2006.
description
xvi, 326 p., [16] p. of plates : ill. (some col.) ; 26 cm.
ISBN
0471160059 (pbk. : alk. paper), 9780471160052
format(s)
Book
Subjects
More Details
imprint
Hoboken, N.J. : Wiley-Liss, c2006.
isbn
0471160059 (pbk. : alk. paper)
9780471160052
restrictions
Licensed for access by U. of T. users.
catalogue key
8040616
 
Includes bibliographical references and index.
A Look Inside
About the Author
Author Affiliation
Timothy D. Veenstra, PhD, is the Director of the Laboratory of Proteomics and Analytical Technologies, National Cancer Institute-Frederick, Frederick, Maryland John R. Yates III, PhD, is in the Department of Cell Biology, The Scripps Research Institute, La Jolla, California
Reviews
Review Quotes
"The authors know what they are talking about and any chapter would make a pretty good stand alone review." ( Genetical Research , 2007)
This item was reviewed in:
SciTech Book News, September 2006
To find out how to look for other reviews, please see our guides to finding book reviews in the Sciences or Social Sciences and Humanities.
Summaries
Back Cover Copy
Tools and guidance from a team of experts to meet the challenges of the post-genomics era Proteomics for Biological Discovery presents the state of the art in the field of proteomics and offers readers new tools and techniques to advance their own research. Moreover, the publication provides readers with an understanding of new and emerging directions for proteomics research and applications.The publication begins with an introduction that examines the rise of proteomics and discusses potential benefits, such as new diagnostics and therapeutics, that further proteome-level research promises. Next, the publication is divided into three sections: Foundations of Proteomics Functional Proteomics Novel Approaches in Proteomics All the tools of proteomics, from conventional to novel techniques, are examined, including: Proteomic analysis using 2D-PAGE Gel-free proteomics to measure protein abundances Characterization of intact noncovalent protein complexes Three-dimensional protein structure determination Protein localization by imaging techniques Protein arrays The publication also covers key foundations of proteomics: separations, bioinformatics, and automation. Each chapter, written by an expert, addresses technological limitations, emerging approaches, and key questions requiring further investigation. In addition, each chapter explores future applications for industry and basic science.This reference brings readers in touch with a team of experts who are leading the proteomics revolution. It is, therefore, recommended for students and researchers across the gamut of fields in biomedical research, including biochemistry, protein chemistry, molecular genetics, cell and developmental biology, and bioinformatics.
Back Cover Copy
Tools and guidance from a team of experts to meet the challenges of the post-genomics era Proteomics for Biological Discovery presents the state of the art in the field of proteomics and offers readers new tools and techniques to advance their own research. Moreover, the publication provides readers with an understanding of new and emerging directions for proteomics research and applications. The publication begins with an introduction that examines the rise of proteomics and discusses potential benefits, such as new diagnostics and therapeutics, that further proteome-level research promises. Next, the publication is divided into three sections: Foundations of Proteomics Functional Proteomics Novel Approaches in Proteomics All the tools of proteomics, from conventional to novel techniques, are examined, including: Proteomic analysis using 2D-PAGE Gel-free proteomics to measure protein abundances Characterization of intact noncovalent protein complexes Three-dimensional protein structure determination Protein localization by imaging techniques Protein arrays The publication also covers key foundations of proteomics: separations, bioinformatics, and automation. Each chapter, written by an expert, addresses technological limitations, emerging approaches, and key questions requiring further investigation. In addition, each chapter explores future applications for industry and basic science. This reference brings readers in touch with a team of experts who are leading the proteomics revolution. It is, therefore, recommended for students and researchers across the gamut of fields in biomedical research, including biochemistry, protein chemistry, molecular genetics, cell and developmental biology, and bioinformatics.
Main Description
Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.
Table of Contents
Contributorsp. vii
Forewordp. xi
Prefacep. xv
Foundations of Proteomicsp. 1
Mass Spectrometry: The Foundation of Proteomicsp. 1
Proteomic Analysis by Two-Dimensional Polyacrylamide Gel Electrophoresisp. 19
Isotope Labeling in Quantitative Proteomicsp. 47
Mass Spectrometric Characterization of Post-translational Modificationsp. 63
Technologies for Large-Scale Proteomic Tandem Mass Spectrometryp. 91
Protein Fractionation Methods for Proteomicsp. 111
Functional Proteomicsp. 135
Protein Localization by Cell Imagingp. 137
Characterization of Functional Protein Complexesp. 157
Structural Proteomics by NMRp. 171
Novel Approaches in Proteomicsp. 187
Protein Microarraysp. 189
Microfluidics-Based Proteome Analysisp. 205
Single Cell Proteomicsp. 225
Diagnostic Proteomicsp. 247
Automation in Proteomicsp. 277
Bioinformatics Tools for Proteomicsp. 289
Indexp. 309
Table of Contents provided by Ingram. All Rights Reserved.

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