Catalogue


Handbook of solubility data for pharmaceuticals [electronic resource] /
Abolghasem Jouyban.
imprint
Boca Raton : CRC Press, c2010.
description
xiii, 538 p. : ill. ; 27 cm.
ISBN
1439804850 (hardcover : alk. paper), 9781439804858 (hardcover : alk. paper)
format(s)
Book
Holdings
More Details
imprint
Boca Raton : CRC Press, c2010.
isbn
1439804850 (hardcover : alk. paper)
9781439804858 (hardcover : alk. paper)
restrictions
Licensed for access by U. of T. users.
contents note
Solubility data in organic solvents -- Solubility data in binary solvent mixtures -- Solubility data in ternary solvent mixtures.
catalogue key
7939597
 
Includes bibliographical references and indexes.
A Look Inside
Summaries
Main Description
Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticalsprovides an extensive database of solubility for pharmaceuticals in mono solvents and binary solvents. Aqueous solubility data can be found in the Handbook of Aqueous Solubility Databy Samuel Yalkowsky and Yan He. Visit www.crcpress.com for more information. In addition to the experimental efforts to measure the solubility of drugs in mono and mixed solvents, this book discusses the advantages and limitations of a number of mathematical models used to predict the solubility in mono or mixed solvent systems. It covers the pharmaceutical cosolvents and other organic solvents that are used in syntheses, separations, and other pharmaceutical processes. The solutes featured include the available data for official drugs, drug candidates, precursors of drugs, metabolites, and degradation products of pharmaceuticals. The author also presents the solubilities of amino acids since they play an important role in peptide drug properties. Collecting drug solubilities in various cosolvents, this time-saving handbook includes the mixtures and model constants needed to predict undetermined solubilities. It describes mathematical models that enable data to be derived and provides estimates on how drugs are likely to behave in a given cosolvent. A software program and associated user manual are available on the author's website.
Back Cover Copy
Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive database of solubility for pharmaceuticals in mono solvents and binary solvents. Aqueous solubility data can be found in the Handbook of Aqueous Solubility Data by Samuel Yalkowsky and Yan He. Visit www.crcpress.com for more information.In addition to the experimental efforts to measure the solubility of drugs in mono and mixed solvents, this book discusses the advantages and limitations of a number of mathematical models used to predict the solubility in mono or mixed solvent systems. It covers the pharmaceutical cosolvents and other organic solvents that are used in syntheses, separations, and other pharmaceutical processes. The solutes featured include the available data for official drugs, drug candidates, precursors of drugs, metabolites, and degradation products of pharmaceuticals. The author also presents the solubilities of amino acids since they play an important role in peptide drug properties.Collecting drug solubilities in various cosolvents, this time-saving handbook includes the mixtures and model constants needed to predict undetermined solubilities. It describes mathematical models that enable data to be derived and provides estimates on how drugs are likely to behave in a given cosolvent. A software program and associated user manual are available on the author's website.
Bowker Data Service Summary
Presenting a comprehensive database of solubility for pharmaceuticals in organic solvents & binary solvent mixtures, this book includes a summary of numerous numerical methods to predict the solubility in mono & mixed solvents & provides the model constants of the Jouyban-Acree model to predict unmeasured solubilities.

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