Catalogue


Functional tissue engineering [electronic resource] /
editors, Farshid Guilak ... [et al.].
imprint
New York : Springer, c2003.
description
xvi, 426 p. : ill. ; 26 cm.
ISBN
0387955534 (alk. paper)
format(s)
Book
Holdings
More Details
added author
imprint
New York : Springer, c2003.
isbn
0387955534 (alk. paper)
restrictions
Licensed for access by U. of T. users.
catalogue key
7927298
 
Includes bibliographical references and index.
A Look Inside
Reviews
Review Quotes
From the reviews:"Functional Tissue Engineering is a useful compilation of research by contributors involved in developing tissues … . It is not easy to extract a decent book from a conference, but the editors have done a very good job … . it will be an invaluable source for those starting a PhD … . I recommend it to those embarking on or already involved in engineering structural tissues. … The chapters are well written … . The book is clearly focused to encompass practical issues, such as the need to create appropriate biomechanical environments … ." (Sheila MacNeil, Materials Today, July/August, 2005)
From the reviews: "Functional Tissue Engineering is a useful compilation of research by contributors involved in developing tissues … . It is not easy to extract a decent book from a conference, but the editors have done a very good job … . it will be an invaluable source for those starting a PhD … . I recommend it to those embarking on or already involved in engineering structural tissues. … The chapters are well written … . The book is clearly focused to encompass practical issues, such as the need to create appropriate biomechanical environments … ." (Sheila MacNeil, Materials Today, July/August, 2005)
To find out how to look for other reviews, please see our guides to finding book reviews in the Sciences or Social Sciences and Humanities.
Summaries
Main Description
-Softcover reprint of a successful hardcover reference (370 copies sold)-Price to be accessible to the rapidly increasing population of students and investigators in the field of tissue engineering-Chapters written by well-known researchers discuss issues in functional tissue engineering as well as provide guidelines and a summary of the current state of technology
Main Description
The goal of tissue engineering is to repair or replace tissues and organs by delivering implanted cells, scaffolds, DNA, proteins, and/or protein fragments at surgery. Tissue engineering merges aspects of engineering and biology, and many rapid achievements in this field have arisen in part from significant advances in cell and molecular biology. Functional Tissue Engineering addresses the key issues in repairing and replacing load-bearing structures effectively. What are the thresholds of force, stress, and strain that normal tissues transmit or encounter? What are the mechanical properties of these tissues when subjected to expected in vivo stresses and strains, as well as under failure conditions? Do tissue engineered repairs and replacements need to exactly duplicate the structure and function of the normal tissue or organ? When developing these implants in culture, how do physical factors such as mechanical stress regulate cell behavior in bioreactors as compared to signals experienced in vivo? And finally, can tissue engineers mechanically stimulate these implants before surgery to produce a better repair outcome? Chapters written by well-known researchers discuss these matters and provide guidelines and a summary of the current state of technology. Functional Tissue Engineering will be useful to students and researchers as it will remind tissue engineers of the clinical importance of restoring function to damaged tissue and structures. Further, the book clarifies the identification of critical structural and mechanical requirements needed for each construct. Functional Tissue Engineering also provides an invaluable resource to help tissue engineers incorporate these functional criteria into the design, manufacture, and optimization of tissue engineered products. Finally it serves as a reference and teaching text for the rapidly increasing population of students and investigators in the field of tissue engineering.
Back Cover Copy
The goal of "tissue engineering" is to repair or replace tissues and organs by delivering implanted cells, scaffolds, DNA, proteins, and/or protein fragments at surgery. Tissue engineering merges aspects of engineering and biology, and many rapid achievements in this field have arisen in part from significant advances in cell and molecular biology. Despite its early successes, however, tissue engineers have faced challenges in repairing or replacing tissues that serve a predominantly biomechanical function. This book addresses and discusses a number of issues that need to be addressed in order for tissue engineers to effectively repair or replace these load-bearing structures. What are the thresholds of force, stress, and strain that normal tissues transmit or encounter? What are the mechanical properties of these tissues when subjected to expected in vivo stresses and strains, as well as under failure conditions? Which of these properties should a tissue engineer insist upon incorporating into the design? Do tissue engineered repairs and replacements need to exactly duplicate the structure and function of the normal tissue or organ in order to be successful? When developing these implants in culture, how do physical factors such as mechanical stress regulate cell behavior in bioreactors as compared to signals experienced in vivo? And finally, can tissue engineers mechanically stimulate these implants before surgery to produce a better repair outcome? Chapters written by well-known researchers discuss these matters and provide guidelines and a summary of the current state of technology in functional tissue engineering. The book will be useful to students and researchers as it will increase awareness among tissue engineers of the importance of restoring "function" when engineering tissue constructs, and identifying the critical structural and mechanical requirements needed for each construct. It will also provide an invaluable source of information to help tissue engineers incorporate these functional criteria into the design, manufacture, and optimization of tissue engineered products. Finally it serves as a reference and teaching text for the rapidly increasing population of students and investigators in the field of tissue engineering.
Main Description
Tissue engineering is an exciting new field at the interface of engineering and biology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Functional Tissue Engineering marks the tremendous progress in biological and biomaterials aspects of this field that have been accomplished to date. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Readers will get an overview designed to increase awareness among tissue engineers about the importance of restoring biomechanical function in the development of living tissue substitutes. Further, the chapter authors identify the critical structural and mechanical requirements needed for each construct and provide a framework for the development of functional criteria in the design, manufacture, and optimization of tissue-engineered constructs. Garnering the expertise of a select group of biomedical engineers, biologists, and clinicians, Functional Tissue Engineering is a necessary resource for students, investigators, and clinicians engaged in this dynamic and exciting area. Book jacket.
Bowker Data Service Summary
The authors address the key issues in repairing & replacing load-bearing structures in the human body effectively. They discuss the thresholds of force, stress & strain imposed on tissue, how these are best accomodated in repair, & also the potential for stimulating implants before surgery.
Main Description
-Softcover reprint of a successful hardcover reference (370 copies sold) -Price to be accessible to the rapidly increasing population of students and investigators in the field of tissue engineering -Chapters written by well-known researchers discuss issues in functional tissue engineering as well as provide guidelines and a summary of the current state of technology
Table of Contents
Prefacep. v
Contributorsp. xiii
The Functional Properties of Native Tissuesp. 1
How Does Nature Build a Tissue?p. 3
Ligament Healing: Present Status and the Future of Functional Tissue Engineeringp. 17
Native Properties of Cardiovascular Tissues: Guidelines for Functional Tissue Engineeringp. 35
Functional Properties of Native Articular Cartilagep. 46
Excitability and Contractility of Skeletal Muscle: Measurements and Interpretationsp. 69
Functional Requirements of Engineered Tissuesp. 85
Functional Requirements for the Engineering of a Blood Vessel Substitutep. 87
In Vivo Force and Strain of Tendon, Ligament, and Capsulep. 96
Requirements for Biological Replacement of the Articular Cartilage at the Knee Jointp. 106
Functional Requirements: Cartilagep. 117
Design Parameters for Tissue Engineeringp. 127
Design Parameters for Functional Tissue Engineeringp. 129
Tissue Engineering a Heart: Critical Issuesp. 139
Design Parameters for Engineering Bone Regenerationp. 146
Tissue Engineering of Bone: The Potential Uses of Gene Therapy for Difficult Bone Loss Problemsp. 162
Engineered Skeletal Muscle: Functional Tissues, Organs, and Interfacesp. 178
Bioengineering the Growth of Articular Cartilagep. 194
Assessment of Function in Engineered Tissuesp. 211
Functional Tissue Engineering: Assessment of Function in Tendon and Ligament Repairp. 213
The Role of Mechanical Forces in Tissue Engineering of Articular Cartilagep. 227
Biomechanics of Native and Engineered Heart Valves Tissuesp. 243
Assessment of Function in Tissue-Engineered Vascular Graftsp. 258
Assessment of the Performance of Engineered Tissues in Humans Requires the Development of Highly Sensitive and Quantitative Noninvasive Outcome Measuresp. 268
Cell-Matrix Interactions in Functional Tissue Engineeringp. 275
Functional Tissue Engineering and the Role of Biomechanical Signaling in articular Cartilage Repairp. 277
Regulation of Cellular Response to Mechanical Signals by Matrix Designp. 291
Artificial Soft Tissue Fabrication from Cell-Contracted Biopolymersp. 305
Cytomechanics: Signaling to Mechanical Load in Connective Tissue Cells and Role in Tissue Engineeringp. 318
Bioreactors and the Role of Biophysical Stimuli in Tissue Engineeringp. 335
The Role of Biomechanics in Analysis of Cardiovascular Diseases: Regulation of the Fluid Shear Response by Inflammatory Mediatorsp. 337
A Full Spectrum of Functional Tissue-engineered Blood Vessels: From Macroscopic to Microscopicp. 347
Engineering Functional Cartilage and Cardiac Tissue: In Vitro Culture Parametersp. 360
Tissue Engineering Skeletal Musclep. 377
Regulatory and Clinical Issues in Tissue Engineeringp. 393
From Concept Toward the Clinic: Preclinical Evaluation of Tissue-Engineered Constructsp. 395
Trends in the FDAp. 400
Indexp. 405
Table of Contents provided by Rittenhouse. All Rights Reserved.

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