Bacterial signal transduction [electronic resource] : networks and drug targets /

Record Details

edited by Ryutaro Utsumi.

imprint

New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, c2008.

description

xvii, 242 p. : ill. (some col.) ; 26 cm.

ISBN

0387788840, 9780387788845

format(s)

Book

Holdings

Web

Scholars Portal Books: Springer

Web

SpringerLINK eBooks - English/International Collection (2008)

Subjects

subject

Bacterial Physiology--drug effects.

Bacterial Proteins--physiology.

Cell Communication--drug effects.

Cell Communication--physiology.

Cellular signal transduction.

Gene Regulatory Networks--drug effects.

Gene regulatory networks--Effect of drugs on.

Molecular microbiology.

Signal Transduction--physiology.

More Details

added author

Utsumi, Ryutaro.

title

Bacterial signal transduction [electronic resource] : networks and drug targets / edited by Ryutaro Utsumi.

series title

Advances in experimental medicine and biology ; v. 631

imprint

New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, c2008.

isbn

0387788840

9780387788845

restrictions

Licensed for access by U. of T. users.

catalogue key

7842095

Includes bibliographical references and index.

A Look Inside

Reviews

Review Quotes

Aus den Rezensionen:"... Dieses Buch â¦ gibt einen vertiefenden Einblick in die KomplexitÃ¤t ausgewÃ¤hlter Histidinkinase/ Antwortregulator-Systeme ... Das Buch ist eine Zusammenstellung aktueller Ãbersichtsartikel zu einzelnen Systemen und liefert somit Wissenschaftlern, die an diesen Themen forschen, eine FÃ¼lle von Daten ..." (Kirsten Jung, in: BIOspektrum, 2009, Vol. 15, Issue 5, S. 581)

Aus den Rezensionen: "... Dieses Buch ... gibt einen vertiefenden Einblick in die Komplexitt ausgewhlter Histidinkinase/ Antwortregulator-Systeme ... Das Buch ist eine Zusammenstellung aktueller bersichtsartikel zu einzelnen Systemen und liefert somit Wissenschaftlern, die an diesen Themen forschen, eine Flle von Daten ..." (Kirsten Jung, in: BIOspektrum, 2009, Vol. 15, Issue 5, S. 581)

Summaries

Bowker Data Service Summary

Recently, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these developments have been put together in this book, with the aim of providing an incentive for researchers to further elucidate the TCS networks and apply them in the search for drugs.

Main Description

This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these developments have been put together in this book, Bacterial Signal Transduction: Networks and Drug Targets. The aim of this book is to provide an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.

Table of Contents

Introduction to Bacterial Signal Transduction Networks	p. 1
Abstract	p. 1
Introduction	p. 1
Mg2+ Stimulon	p. 1
EvgS/EvgA TCS	p. 2
Signal Transduction Cascade between EvgS/EvgA and PhoQ/PhoP TCSs	p. 5
Future Perspectives	p. 5
The Phoq/Phop Regulatory Network of Salmonella Enterica	p. 7
Abstract	p. 7
Introduction	p. 7
The Salmonella phoP Gene: from Phosphatase Regulator to Virulence Controller	p. 8
Structural and Functional Properties of the PhoP and PhoQ Proteins	p. 8
Defining the PhoP Regulon	p. 9
Direct Transcriptional Control by the PhoP Protein	p. 9
The How and Why of PhoQ/PhoP Positive Autoregulation	p. 11
Indirect and Nontraditional Transcriptional Control by the PhoP Protein	p. 12
Typical and Atypical Transcriptional Cascades	p. 12
A Feedforward Loop Regulating Expression of Horizontally-Acquired Genes	p. 14
PhoP as a Co-Activator Protein	p. 14
Connector Proteins that Regulate Response Regulators	p. 16
The Biological Consequences of Different Network Designs	p. 17
Conclusions	p. 18
Structural Basis of The Signal Transduction in The Two-Component System	p. 22
Abstract	p. 22
Introduction	p. 22
Structures of Each Domain in Two-Component System	p. 24
Signal Transduction in Histidine Kinase	p. 28
Oxygen Sensor FixL/FixJ System	p. 32
Conclusions	p. 36
The Two-Component Network and the General Stress Sigma Factor Rpos (¿s) in Escherichia Coli	p. 40
Abstract	p. 40
Introduction	p. 40
Regulation of RpoS	p. 41
The Response Regulator RssB Acts as a Targeting Factor in RpoS Proteolysis	p. 42
The Role of RssB in the Regulation of RpoS Proteolysis by Environmental Signals	p. 44
The ArcB/ArcA/RssB "Three-Component" System Coordinates RpoS Expression and Proteolysis with Energy Metabolism	p. 45
Role of the RpoS/RssB Feedback Cycle	p. 47
Role of the IraP Protein as an Antagonist of RssB	p. 47
Effects of RssB on Other Two-Component Systems	p. 47
Role of the BarA/UvrY Phosphorelay System in RpoS Transcription	p. 48
Role of the Rcs Phosphorelay System in RpoS Translation	p. 48
RpoS-Regulated Two-Component Systems	p. 49
Conclusions and Perspectives	p. 49
Small RNAS Controlled by Two-Component Systems	p. 54
Abstract	p. 54
Introduction	p. 54
Antisense Control of Translation Initiation and mRNA Stability	p. 55
Sequestration of RNA-Binding Proteins	p. 59
Combination of Antisense and Sequestration Mechanisms	p. 70
Concluding Remarks	p. 71
Two-Component Signaling and Gram Negative Envelope Stress Response Systems	p. 80
Introduction	p. 80
The ¿E Envelope Stress Response	p. 81
The Cpx Two-Component System	p. 87
The Bae Two-Component System	p. 94
The Phage-Shock-Protein (Psp) Response	p. 95
The Rcs Phosphorelay System	p. 99
Dual Regulation with SER/THR Kinase Cascade and a HIS/ASPTCS in Myxococcus Xanthus	p. 111
Abstract	p. 111
Introduction	p. 111
FruA: A Key Developmental Transcription Factor	p. 113
MrpC: A Transcriptional Activator for fruA Expression	p. 113
Genetic Study of the mrpC Locus	p. 113
MrpC Binding Sites in mrpC and fruA Promoter Regions	p. 115
Regulation of mrpC Expression Mediated by MrpA, MrpB and MrpC	p. 115
Pkn8-Pkn14 Kinase Cascade	p. 116
mrpC Expression in pkn8 and pkn14-Deletion Strains during Vegetative Growth	p. 117
MrpC2, a Major Regulator for mrpC and fruA Expression	p. 117
Inhibition by Pkn8-Pkn14 Kinase Cascade on MrpC/MrpC2 Expression during Vegetative Growth	p. 118
Overview	p. 118
Two-Component Signaling Systems and Cell Cycle Control in Caulobacter Crescentus	p. 122
Abstract	p. 122
Introduction	p. 122
Caulobacter crescentus: A Dimorphic Bacterial Model for Cell Cycle Regulation	p. 123
CtrA, GcrA and DnaA: Global Regulators of Cell Cycle Progression	p. 123
Transcriptional Control of CtrA	p. 125
Proteolytic Control of Cell Cycle Regulatory Proteins	p. 126
Phosphorylative Control of Cell Cycle Regulatory Proteins	p. 127
Upstream Cell Cycle Control by Opposing Kinases	p. 127
Network Control of Histidine Kinase Localization and Polar Morphogenesis	p. 128
The Search for Regulatory Signals	p. 128
REGB/REGA, A Global Redox-Responding Two-Component System	p. 131
Abstract	p. 131
Introduction	p. 131
Members of the Reg Regulon	p. 136
The Sensor Kinase RegB	p. 140
The Response Regulator RegA	p. 143
DNA-Binding Sites	p. 144
Concluding Remarks	p. 145
The BVGS/BVGA Phosphorelay System of Pathogenic Bordetellae: Structure, Function and Evolution	p. 149
Abstract	p. 149
Introduction	p. 149
Phenotypic Phases in the Expression of the Virulence Factors of B. pertussis	p. 150
Structure Function Relationships in the BvgS/BvgA Phosphorelay System	p. 153
BvgA-DNA Interactions	p. 153
Fine Tuning of the Activity of the BvgS/BvgA Phosphorelay	p. 155
Relevance of BvgS/BvgA Mediated Gene Regulation during the Infection Process	p. 156
Evolutionary Considerations	p. 156
Capturing The VIRA/VIRG TCS of Agrobacterium Tumefaciens	p. 161
Abstract	p. 161
Introduction	p. 161
Signal Perception and Transmission	p. 165
Antibiotic Development	p. 172
Perspective	p. 173
Quorum Sensing and Biofilm Formation by Streptococcus Mutans	p. 178
Abstract	p. 178
Introduction	p. 178
Virulence Properties of S. mutans	p. 179
Quorum Sensing System in S. mutans	p. 180
Quorum Sensing and Biofilm Formation in S. mutans	p. 182
Density-Dependent Production of Bacteriocins: Implications on Survival in Plaque	p. 184
Quorum Sensing-Dependent Growth Arrest and Cell Death	p. 184
Effect of Other Signal Transduction Systems on S. mutans Biofilm Formation	p. 184
Future Perspectives	p. 186
The Roles of Two-Component Systems in Virulence of Pathogenic Escherichia Coli and Shigella SPP	p. 189
Abstract	p. 189
Introduction	p. 189
Genome Structure of Pathogenic E. coli and Shigella spp.	p. 190
Two-Component Systems (TCSs) in Virulence Expression	p. 191
Conclusion	p. 197
Vancomycin Resistance VANS/VANR Two-Component Systems	p. 200
Abstract	p. 200
Introduction	p. 200
A Range of Different VanS/VanR Systems	p. 202
What Do the van Genes Encode?	p. 203
VanS/VanR Biochemistry	p. 204
VanS/VanR and Acetyl Phosphate	p. 205
'Crosstalk' with Other Two-Component Systems	p. 205
Relationships Between VanS Proteins of Different Origin	p. 206
What Is the Effector Ligand Recognised by VanS?	p. 208
Functional Differences between Vancomycin and Teicoplanin	p. 209
Evolution of the van Cluster	p. 210
Tearing Down the Wall: Peptidoglycan Metabolism and the WALK/WALR (YycG/YycF) Essential Two-Component System	p. 214
Abstract	p. 214
Introduction	p. 214
walRK Operon Structure	p. 215
The WalK Histidine Kinase	p. 216
The WalR Response Regulator	p. 218
A Matter of Life and Death: To Be or Not to Be Essential	p. 218
Global Analyses of WalKR-Regulated Genes Reveal a Major Role in Cell Wall Homeostasis	p. 220
walRK Operon Expression	p. 222
DNA Sequence Targeted by the WalR Regulator	p. 223
Phenotypes Associated with a Defect in WalKR Activity	p. 223
Impact of the WalKR System on Virulence	p. 224
The WalKR TCS as a Target for Antimicrobial Therapy: A Bacterial Achille's Heel?	p. 225
Inhibitors Targeting Two-Component Signal Transduction	p. 229
Abstract	p. 229
Introduction	p. 229
HK Inhibitors	p. 230
Inhibitors Targeting an Essential TCS, YycG/YycF	p. 232
Structure-Based Virtual Screening	p. 234
Index	p. 237
Table of Contents provided by Ingram. All Rights Reserved.

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