Catalogue


Cancer stem cells : novel concepts and prospects for tumor therapy /
O. D. Wiestler, B. Haendler, D. Mumberg, editors.
imprint
Berlin ; New York : Springer, 2007.
description
xvi, 263 p. : ill. ; 22 cm.
ISBN
3540708529 (alk. paper), 9783540708520 (alk. paper)
format(s)
Book
Holdings
More Details
imprint
Berlin ; New York : Springer, 2007.
isbn
3540708529 (alk. paper)
9783540708520 (alk. paper)
contents note
Niche for normal and cancer stem cells / S.-I. Nishikawa, M. Osawa -- c-Myc and activated Ras during skin tumorigenesis : cooperation at the cancer stem cell level? / A. Trumpp -- Wnt signaling in stem cells and lung cancer / B. He, D.M. Jablons -- Bone morphogenetic proteins regulate tumorigenicity in human glioblastoma stem cells / S.G.M. Piccirillo, A.L. Vescovi -- Strategies to induce nuclear reprogramming / S. Eminli, R. Jaenisch, K. Hochedlinger -- The intestinal stem cell niche studied through conditional transgenesis / A.R. Clarke, V. Meniel -- The migrating cancer stem cells model--a conceptual explanation of malignant tumour progression / A. Jung, T. Brabletz, T. Kirchner -- Bone marrow niche and leukemia / A.D. Ho, W. Wagner -- Breast stem cells and cancer / G. Farnie, R.B. Clarke -- Prostate cancer stem cells : a target for new therapies / N.J. Maitland, ... [et al.] -- The hedgehog signaling network, mammary stem cells, and breast cancer : connections and controversies / M.T. Lewis, A.P. Visbal -- Strategies to eliminate cancer stem cells / R.J. Jones -- DNA repair in stem cell maintenance and conversion to cancer stem cells / S.L. Gerson, J. Reese, J. Kenyon -- Tumorigenic epithelial stem cells and their normal counterparts / V.S. Donnenberg, ... [et al.]
catalogue key
6297663
 
Includes bibliographical references.
A Look Inside
Summaries
Main Description
Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study endpoints.
Back Cover Copy
This book describes the recent developments in the emerging field of cancer stem cells. Their possible impact for the identification of novel treatment paradigms for cancer are discussed. The book will mainly be of interest to scientists and clinicians involved in cancer research, or to students wishing to enter into this area.
Long Description
Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells offers great therapeutic opportunities but also provides for major challenges regarding preclinical models, therapeutic windows, and clinical study end points.
Main Description
Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer.
Table of Contents
Niche for Normal and Cancer Stem Cellsp. 1
c-Myc and Activated Ras During Skin Tumorigenesis: Cooperation at the Cancer Stem Cell Level?p. 13
Wnt Signaling in Stem Cells and Lung Cancerp. 27
Bone Morphogenetic Proteins Regulate Tumorigenicity in Human Glioblastoma Stem Cellsp. 59
Strategies to Induce Nuclear Reprogrammingp. 83
The Intestinal Stem Cell Niche Studied Through Conditional Transgenesisp. 99
The Migrating Cancer Stem Cells Model - A Conceptual Explanation of Malignant Tumour Progressionp. 109
Bone Marrow Niche and Leukemiap. 125
Breast Stem Cells and Cancerp. 141
Prostate Cancer Stem Cells: A Target for New Therapiesp. 155
The Hedgehog Signaling Network, Mammary Stem Cells, and Breast Cancer: Connections and Controversiesp. 181
Strategies to Eliminate Cancer Stem Cellsp. 219
DNA Repair in Stem Cell Maintenance and Conversion to Cancer Stem Cellsp. 231
Tumorigenic Epithelial Stem Cells and Their Normal Counterpartsp. 245
Table of Contents provided by Ingram. All Rights Reserved.

This information is provided by a service that aggregates data from review sources and other sources that are often consulted by libraries, and readers. The University does not edit this information and merely includes it as a convenience for users. It does not warrant that reviews are accurate. As with any review users should approach reviews critically and where deemed necessary should consult multiple review sources. Any concerns or questions about particular reviews should be directed to the reviewer and/or publisher.

  link to old catalogue

Report a problem