Catalogue


Nucleic acid therapeutics in cancer /
edited by Alan M. Gewirtz.
imprint
Totowa, N.J. : Humana Press, c2004.
description
x, 219 p.
ISBN
1588292584 (alk. paper)
format(s)
Book
Holdings
More Details
imprint
Totowa, N.J. : Humana Press, c2004.
isbn
1588292584 (alk. paper)
general note
Papers from a conference held Apr. 2000 in Bryn Mawr, Pa.
catalogue key
5149461
 
Includes bibliographical references and index.
A Look Inside
Reviews
This item was reviewed in:
SciTech Book News, June 2004
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Summaries
Long Description
A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.
Main Description
Since nucleic acid therapeutics, with its promise of exquisite molecular specificity and concordant limited toxicity, continue to be highly attractive pharmaceutical prospects, this volume pursues the goal of making useful "antisense" drugs. This volume discusses the limited ability to deliver oligonucleotide (OLG) into cells in order for them to reach their target, This volume also addresses the issues that are slowing progress in this field such as the ability of an OLG to anneal to an accessible sequence within the target mRNA. Providing an overview of the significant issues in this field, Nucleic Acid Therapeutics in Cancer looks toward the development of simple, reliable tools for modifying gene expression.
Unpaid Annotation
Since nucleic acid therapeutics, with its promise of exquisite molecular specificity and concordant limited toxicity, continue to be highly attractive pharmaceutical prospects, this volume pursues the goal of making useful "antisense" drugs. Providing an overview of the significant issues in this field, Nucleic Acid Therapeutics in Cancer looks toward the development of simple, reliable tools for modifying gene expression.
Unpaid Annotation
This volume presents a cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.
Unpaid Annotation
A cutting-edge review of the important issues underlying the therapeutic use of nuclei acidmediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA.
Back Cover Copy
The development of effectively targeted and efficiently delivered nucleic acids promises important advances in the diagnosis and treatment of human malignancies. In Nucleic Acid Therapeutics in Cancer, leading researchers, academic physicians, and clinicians clearly and succinctly review the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting methods and specific clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically. Concise yet highly readable, Nucleic Acid Therapeutics in Cancer offers those who require a cutting-edge critical synthesis not only a state-of-the-art account of this promising field, but also an illuminating introduction to their emerging therapeutic uses.
Table of Contents
Prefacep. v
Contributorsp. ix
Introduction and Perspective
Antisense Methodology: An Assessment After 25 Yearsp. 3
Nucleic Acid Therapeutics: An Introductionp. 15
Basic Methodology
Targeted Genome Modification Via Triple Helix Formationp. 27
Therapeutic Applications of Ribozymesp. 45
Use of Catalytic DNA in Target Validation and Therapeuticsp. 65
Targeted Destruction of Small, Stable RNAs: Principles Applicable to Antisense Therapiesp. 81
Mechanism of Action of Antisense RNA in Eukaryotic Cellsp. 89
Delivery
The Transport of Oligonucleotides Into Cellsp. 107
Peptide-Mediated Delivery of Antisense Oligonucleotides and Related Materialp. 115
Molecular Vectors for Gene Delivery to Cancer Cellsp. 129
Targeting
Considerations on the Design of Antisense Oligonucleotidesp. 143
Identification of Hybridization Accessible Sequence in Messenger RNAp. 155
Clinical Targets
Nucleic Acids As Gene Targeting Therapeuticsp. 167
LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen): Phosphorothioate Antisense Oligonucleotides With Pleiotropic Mechanisms of Actionp. 177
Antisense Protein Kinase A-RI[alpha] Restores Normal Signal Transduction Signatures to Inhibit Tumor Growthp. 199
Indexp. 213
Table of Contents provided by Rittenhouse. All Rights Reserved.

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