Catalogue


Advancing prion science : guidance for the national prion research program /
Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science ; Rick Erdtmann and Laura B. Sivitz, editors.
imprint
Washington, DC : National Academies Press, c2004.
description
xvii, 258 p. : ill. ; 23 cm.
ISBN
0309090601 (pbk.)
format(s)
Book
Holdings
More Details
imprint
Washington, DC : National Academies Press, c2004.
isbn
0309090601 (pbk.)
contents note
Executive summary -- Prion diseases: an overview -- Diagnostics for transmissible spongiform encephalopathies -- Testing blood for evidence of transmissible spongiform encephalopathies in the United States -- Assessment of strategies to prevent and treat transmissible spongiform encephalopathies -- Infrastructure for research on transmissible spongiform encephalopathies -- Risks of transmissible spongiform encephalopathies to the U.S. military.
catalogue key
5136860
 
Includes bibliographical references.
A Look Inside
Reviews
This item was reviewed in:
Doody's Reviews, March 2005
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Summaries
Description for Bookstore
In Advancing Prion Science , the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs-from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
Description for Bookstore
In Advancing Prion Science , the Institute of Medicine’s Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense’s National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions’ normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs-from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
Description for Bookstore
In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs-from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
Long Description
In Advancing Prion Science , the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs--from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
Table of Contents
Executive Summaryp. 1
Summaryp. 5
Origins of This Studyp. 6
Prions and PrP[superscript Sc]: Definitions and Usagep. 8
Basic Biomedical Researchp. 9
TSE Diagnosticsp. 10
Testing Blood for Evidence of TSEsp. 13
Surveillance for TSEs in the United Statesp. 14
Assessment of Strategies to Prevent and Treat TSEsp. 17
Research Infrastructurep. 22
The Risk of TSEs to the U.S. Militaryp. 24
Conclusionp. 25
Referencesp. 29
Introductionp. 33
Charge to the Committeep. 35
Organization of the Reportp. 35
Referencesp. 38
Prion Diseases: An Overviewp. 39
Origins and Development of Prion Sciencep. 40
The Nature of Prions and Prion Proteinp. 43
The Epidemic of BSE and the Emergence of vCJDp. 49
Global Impact of BSE and vCJDp. 52
The Spread of Chronic Wasting Disease in the United Statesp. 53
Unique Challenges in Conducting TSE Researchp. 54
Referencesp. 55
Basic Biomedical Research on Transmissible Spongiform Encephalopathiesp. 60
Structural Features of Prionsp. 61
Molecular Mechanisms of Prion Replicationp. 62
Mechanisms of TSE Pathogenesisp. 63
Physiological Function of PrP[superscript C]p. 67
Referencesp. 68
Diagnostics for Transmissible Spongiform Encephalopathiesp. 72
Clinical Diagnosticsp. 74
Current Laboratory Diagnosticsp. 79
Newer, Experimental Diagnostics for Laboratory Usep. 89
Research Recommendations for TSE Diagnosticsp. 94
Referencesp. 101
Testing Blood for Evidence of the Agents of Transmissible Spongiform Encephalopathiesp. 108
Animal Studies to Assess TSE Infectivity of Bloodp. 109
Risk of Human-to-Human Transmission of TSE Agents by Transfusion and Transplantp. 112
Blood Tests for TSE Agentsp. 114
Referencesp. 122
Surveillance for Transmissible Spongiform Encephalopathies in the United Statesp. 125
U.S. Surveillance for Human TSEsp. 126
U.S. Surveillance for TSEs in Animalsp. 137
Essential Research to Improve U.S. Capabilities to Conduct Surveillance for TSEsp. 150
Referencesp. 154
Assessment of Strategies to Prevent and Treat Transmissible Spongiform Encephalopathiesp. 160
Measures to Prevent the BSE Agent from Entering the U.S. Food Chainp. 160
Measures to Prevent the CWD Agent from Entering the U.S. Food Chainp. 178
Preventing TSE Transmission Through Blood, Blood Derivatives, and Transplanted Tissuesp. 184
Inactivation of Prions on Surfaces and in the Environmentp. 188
Vaccination as a Preventive Strategyp. 195
Progress in Therapy for TSEsp. 196
Referencesp. 205
Infrastructure for Research on Transmissible Spongiform Encephalopathiesp. 214
Present U.S. Infrastructurep. 214
Need for Consistent, Science-Based Standards for Biological Safety Levels in TSE Laboratoriesp. 216
Need for Standardized Reagents and Materialsp. 217
Opportunities for International Collaborationp. 220
Referencesp. 221
Risks of Transmissible Spongiform Encephalopathies to the U.S. Militaryp. 223
Risk of Exposure to Beef Products Containing BSE Infectivityp. 224
Risk of TSE Infection from Blood Productsp. 227
Summary of Overall Riskp. 228
Referencesp. 229
Appendixes
Agendas of Open Sessions of Committee Meetingsp. 233
Biographical Sketchesp. 243
Glossaryp. 250
Table of Contents provided by Rittenhouse. All Rights Reserved.

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