Catalogue


Alkaloids : nature's curse or blessing? /
Manfred Hesse.
imprint
Zürich : Verlag Helvetica Chimica Acta ; Weinheim ; New York : Wiley-VCH, 2002.
description
xii, 413 p. : ill. (some col.) ; 24 cm.
ISBN
3906390241
format(s)
Book
Holdings
Subjects
More Details
imprint
Zürich : Verlag Helvetica Chimica Acta ; Weinheim ; New York : Wiley-VCH, 2002.
isbn
3906390241
general note
"Translated by Andrew Beard".
catalogue key
4872720
 
Includes bibliographical references and index.
A Look Inside
Reviews
Review Quotes
"...an insightful treatment of a complex subject and a valuable reference source..."(Chemistry in Britain, October 2002) "...a very handsome book for the coffee table..." (Perkin Transactions, Vol.1, No.23, 2002) "The reviewer must confess that he could not put the book down...most medicinal chemists would find it an appealing choice for pleasure reading...highly recommended." ( Journal of Medicinal Chemistry , Vol. 46, No. 5) "...The book is beautifully produced with many excellent figures and photographs. As a book for the interested chemical scientists it serves it intended remit excellently"(Chemistry & Industry, 19May 2003)
"...an insightful treatment of a complex subject and a valuable reference source..."(Chemistry in Britain, October 2002) "...a very handsome book for the coffee table..." (Perkin Transactions, Vol.1, No.23, 2002) "The reviewer must confess that he could not put the book down...most medicinal chemists would find it an appealing choice for pleasure reading...highly recommended." ( Journal of Medicinal Chemistry , Vol. 46, No. 5) "...The book is beautifully produced with many excellent figures and photographs.' As a book for the interested chemical scientists it serves it intended remit excellently" (Chemistry & Industry, 19May 2003) A"...gives an excellent survey of the known classes of alkaloids, is remarkably comprehensive, and is further enhanced by the aesthetically pleasing and consistent style of the structural formulas..." ( ngewandte Chemie , International EditionVol. 42)
"...an insightful treatment of a complex subject and a valuable reference source..."(Chemistry in Britain, October 2002)"...a very handsome book for the coffee table..." (Perkin Transactions, Vol.1, No.23, 2002)"The reviewer must confess that he could not put the book down...most medicinal chemists would find it an appealing choice for pleasure reading...highly recommended." (Journal of Medicinal Chemistry, Vol. 46, No. 5)"...The book is beautifully produced with many excellent figures and photographs.' As a book for the interested chemical scientists it serves it intended remit excellently" (Chemistry & Industry, 19May 2003)A"...gives an excellent survey of the known classes of alkaloids, is remarkably comprehensive, and is further enhanced by the aesthetically pleasing and consistent style of the structural formulas..." (ngewandte Chemie, International EditionVol. 42)
This item was reviewed in:
SciTech Book News, December 2002
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Summaries
Bowker Data Service Summary
Divided into three section, this volume provides a concise overview of the structure, properties and history of alkaloids.
Main Description
As numerous historical documents - on fireclay, papyrus, or paper - testify, alkaloids, nitrogen contining natural substances, have been companions of mankind from ancient time. Valued as drugs and stimulants, some species are also feared because of their addictive potential, and often it seems impossible to distinguish these effects unambiguously. The chemistry of alkaloids has been captivating chemists for ages and generations. This is the first comprehensive reference work providing a concise overview of structure, properties, and history of these unique and fascinating substances! The volume is organised into three main sections. Part 1 examines the chemically relevant aspects by means of carefully selected examples. After a structural classification, structure elucidation (including common pitfalls) is discussed. Moreover, chiroptical properties and synthetic pathways are detailed. Part 2 is devoted to biological and biochemical aspects. It rationalizes chemotaxonomy and biogenesis by means of examples (indole and 1-benzyl isoquinoline alkaloids) and presents details about the functionality of several alkaloids produced by plants and animals. Part 3 finally describes the cultural and historical significance of the most important alkaloid sources. Exciting anecdotes and historical reports illuminate the use of hemlock, ergot, opium, tobacco, coffee, and cinchona, to name only a few. The unique and comprehensive explanation of the most important features of alkaloids makes this book a compendium valuable not only for experts but also for the layman interested in pharmacy.
Table of Contents
Introductionp. 1
The Term 'Alkaloid'p. 1
On Alkaloid Terminology and Nomenclaturep. 5
Classification of Alkaloidsp. 11
Generalp. 11
Heterocyclic Alkaloidsp. 13
Alkaloids with Exocyclic N-Atoms and Aliphatic Aminesp. 76
Putrescine, Spermidine, and Spermine Alkaloidsp. 82
Peptide Alkaloidsp. 84
Terpene and Steroid Alkaloidsp. 84
Dimeric Alkaloids ('Bis-Alkaloids')p. 91
Structure Elucidation of Alkaloidsp. 115
Introductionp. 115
Isolation of Alkaloids from Plantsp. 116
Structure Elucidation of Coniinep. 118
Applications of Chemical and Spectroscopic Methods in Structure Elucidation: Villalstoninep. 125
Structure Elucidation of the Components of a Naturally Occurring Mixture of Extremely Small Quantitites of Substances: Pollen of Hippeastrum x hortorump. 152
Artifactsp. 169
Introductionp. 169
Acetonep. 169
Ammoniap. 173
Formaldehydep. 174
Chloroformp. 176
Atmospheric Oxygenp. 177
Atmospheric Oxygen and Lightp. 178
Chiroptical Properties of Alkaloidsp. 185
Generalp. 185
Influence of Solventp. 185
Free Base vs. Hydrochloride: Mayfolinep. 186
Racemic and Partially Racemic Mixturesp. 187
The Unexpected Inversion at the N-Atom of (+)-9-O-Demethylhomolycorinep. 194
Morphinesp. 196
Alkaloid Synthesisp. 203
Generalp. 203
The First Total Synthesis of an Alkaloid: (+)-Coniinep. 203
The Synthesis of Mesembrinep. 206
A Biomimetic Synthesis of Porantherinep. 208
Syntheses of Macrocyclic Spermidine Alkaloids: (+)-Cyclocelabenzine and (+)-Isocyclocelabenzinep. 213
The Synthesis of (3S, 14S, 16S)-Vincaminep. 224
Partial Synthesis of the Bisindole Alkaloid Alloferinp. 230
Alkaloids and Chemotaxonomyp. 237
Generalp. 237
Chemotaxonomy and Biogenesis of Indole Alkaloidsp. 239
Aspects of Alkaloid Biogenesisp. 257
Generalp. 257
1-Benzylisoquinoline Alkaloidsp. 259
Biological Significance of Alkaloidsp. 283
Generalp. 283
Antifungal Activityp. 284
Alkaloids as Protectors against UV Irradiationp. 285
Hydroxamic Acids as Insecticides, Herbicides, Fungicides, and Siderophoresp. 287
Alkaloids as Feeding Deterrentsp. 291
Alkaloids from Animalsp. 293
Alkaloid Content of Plants: Local Differences and Changes over Timep. 298
Alkaloids as Medicinesp. 303
Historical Aspects of Alkaloid Chemistryp. 313
Active Principles from Selected Alkaloid Sources and Their Cultural and Historical Significancep. 325
Generalp. 325
Hemlock (Conium maculatum L.)p. 326
Fly Agaric (Amanita muscaria)p. 329
Ergotp. 330
Opiump. 338
The Coca Plant (Erythroxylum coca)p. 350
Deadly Nightshade (Atropa belladonna)p. 351
Betelp. 357
Tobacco (Nicotiana tabacum)p. 358
Mandrake (Mandragora officinarum)p. 365
Cinchona Bark (Peruvian, Fever, or Jesuit's Bark)p. 366
Coffee (Coffea arabica)p. 367
Tea (Camellia sinensis)p. 373
Cocoa (Theobroma cacao)p. 378
Indexp. 383
Table of Contents provided by Syndetics. All Rights Reserved.

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