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Simulation for designing clinical trials : a pharmacokinetic-pharmacodynamic modeling perspective /
edited by Hui C. Kimko, Stephen B. Duffull.
New York : Marcel Dekker, c2003.
xviii, 396 p. : ill.
0824708628 (alk. paper)
More Details
New York : Marcel Dekker, c2003.
0824708628 (alk. paper)
catalogue key
Includes bibliographical references and index.
A Look Inside
This item was reviewed in:
SciTech Book News, March 2003
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Main Description
Details essential components of performing simulation for designing clinical trials via pharmacokinetic-pharmacodynamic modeling. Offers a wide range of applications for optimizing sampling strategies, selecting dosage, and predicting drug efficacy and side effects via clinical trial simulation.
Main Description
Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to clinical trial designs according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.
Table of Contents
Introduction to Simulation for Design of Clinical Trials
Models for Simulation
Computation in Simulation
Analyses of the Simulations
Perspectives on Clinical Trial Simulation
Table of Contents provided by Publisher. All Rights Reserved.

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