Intractable seizures : diagnosis, treatment, and prevention /
edited by W. McIntyre Burnham, Peter L. Carlen, and Paul A. Hwang.
New York : Kluwer Academic/Plenum Publishers, c2002.
xiv, 248 p. : ill. ; 26 cm.
More Details
New York : Kluwer Academic/Plenum Publishers, c2002.
catalogue key
Includes bibliographical references and index.
A Look Inside
Main Description
About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called 'intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major 'intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.
Table of Contents
Intractable Epilepsy in Adultsp. 1
Complex Partial Seizures
Clinical Description and Diagnosisp. 9
Drug Therapy for Complex Partial Seizuresp. 19
Surgery for Complex Partial Seizuresp. 27
West's Syndrome (Infantile Spasms)
Clinical Description and Diagnosisp. 33
Drug Therapy for West's Syndromep. 51
Surgery for West's Syndromep. 57
Lennox-Gastaut Syndrome
Clinical Description and Diagnosisp. 61
Drug Therapy in Lennox-Gastaut Syndromep. 77
Surgery in Lennox-Gastaut Syndrome: Corpus Callosum Division for Childrenp. 87
Special Topic
Early versus Late Surgery in Intractable Seizuresp. 99
Basic Pathophysiology - Theories and Research
Why are Complex Partial Seizures Intractable?p. 107
Pathophysiology of Infantile Spasmsp. 111
Functional Properties of Human Neocortical Neurons: A Window to the Physiopathogenesis of Seizures in Patients with Cortical Dysplasiap. 123
Effects of Unchecked Seizures - Human and Animal Studies
Psychiatric Aspects of Intractable Epilepsyp. 133
Neural Growth, Neural Damage, and Neurotrophins in the Kindling Model of Epilepsyp. 149
Effects of Uncontrolled Seizures: Neural Changes in Animal Modelsp. 171
New Therapeutic Strategies
The Landau-Kleffner Syndromep. 195
Neuroprotective Strategies in Epilepsyp. 209
The Ketogenic Dietp. 225
Vagal Stimulation for Intractable Seizuresp. 233
Indexp. 241
Table of Contents provided by Blackwell. All Rights Reserved.

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