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Xenotransplantation /
edited by Jeffrey L. Platt.
Washington, D.C. : ASM Press, c2001.
x, 298 p. : ill. ; 26 cm.
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Washington, D.C. : ASM Press, c2001.
catalogue key
Includes bibliographical references and index.
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This item was reviewed in:
SciTech Book News, June 2001
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Unpaid Annotation
The use of animals as a source of cells, tissues, and organs for transplantation has been of increasing interest in recent years. Transplantation of animal tissues into human patients is occurring now at various centers and the possibility of organ xenotransplants is widely discussed. This volume presents a balanced review of recent progress in understanding the immunologic aspects of xenotransplantation and zoonotic risks. It addresses how the application of various immunosuppressive modalities might compromise the immunological competence of recipients and examines the relevant issues relating to zoonotic disease. This is the first book to deal with the issues of host defense and zoonosis in xenotransplantation and points to the critical issues that must be addressed to make the process safe from the perspective of the patient and society as well as critical questions yet to be answered. Valuable reading for physicians, scientists, and those engaged in the development of policies for the field of xenotransplantation, especially with regard to zoonosis.
Table of Contents
Contributorsp. vii
Prefacep. ix
A Primer on Xenotransplantationp. 3
Coming to Terms with Reality: Why Xenotransplantation Is a Necessityp. 29
Immunological Hurdles to Xenotransplantation
The Complement System as a Hurdle to Xenotransplantationp. 55
NK Cells as a Barrier to Xenotransplantationp. 85
Cellular Immune Responses to Xenograftsp. 99
Therapeutic Strategies for Xenotransplantationp. 117
Impact of Therapeutic Manipulations on the Host Response to Infection
Manipulation of the Humoral Immune System and the Host Immune Response to Infectionp. 139
Complement Regulation and the Host Response to Infectionp. 159
Recognition of Foreign Antigen and Foreign Major Histocompatibility Complexp. 175
Zoonosis in Xenotransplantation
Xenotransplantation as a Vector for Infectionp. 193
Zoonosis as a Risk to the Xenograft Recipient and to Society: Theoretical Issuesp. 207
Zoonotic Agents in Swine-to-Human Xenotransplantsp. 217
Retroviruses and Xenotransplantationp. 239
Potential Medical Impact of Endogenous Retrovirusesp. 251
Prevention of Infection in Xenotransplantationp. 261
Indexp. 291
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