Essential concepts in clinical research : randomised controlled trials and observational epidemiology /
Kenneth Schulz, David A. Grimes ; foreword by Richard Horton.
Second edition.
Edinburgh : Elsevier, 2019.
1 online resource (x, 256 pages) : color illustrations
0702073938, 0702073946, 9780702073939, 9780702073946
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Edinburgh : Elsevier, 2019.
Licensed for access to Sinai Health System users
contents note
Introduction. An overview of clinical research: the lay of the land -- Observational studies. Descriptive studies: what they can and cannot do -- Bias and causal associations in observational research -- Cohort studies: marching towards outcomes -- Case-control studies: research in reverse -- Finding controls for case-control studies: compared to what? -- Limitations of observational epidemiology -- Screening tests. Uses and abuses of screening tests -- Refining clinical diagnosis with likelihood ratios -- Randomized controlled trials. Boosting participant recruitment in trials -- Sample size calculations in randomized trials: mandatory and mystical -- Generation of allocation sequences in randomized trials: chance not choice -- Generation of allocation sequences in non-double-blinded randomized trials: guarding against guessing -- Allocation concealment in randomized trials: defending against deciphering -- Exclusions and losses in randomized trials: sample size slippages -- Blinding in randomized trials: hiding who got what -- Implementing treatment blinding in randomized trials -- Surrogate endpoints and composite outcomes: shortcuts to unknown destinations -- Multiplicity in randomized trials I: endpoints and treatments -- Multiplicity in randomized trials II: subgroup and interim analyses -- Conducting randomized trials as part of a prospective meta-analysis -- Publishing. Reporting studies in medical journals: CONSORT and other guidelines.
general note
Revised edition of: The Lancet handbook of essential concepts in clinical research / by Kenneth F. Schulz, David A. Grimes ; foreword by Richard Horton. 2006.
"This practical guide speaks to two audiences: those who read and those who conduct research. Clinicians are medical detectives by training. For each patient, they assemble clinical clues to establish causes of signs and symptoms. The task involves both clinical acumen and knowledge of medical research. This book helps guide clinicians through this detective work, by enabling them to make sense of research and to review medical literature critically. It will also be invaluable to researchers who conduct clinical research, particularly randomized controlled trials"--Publisher's description.
catalogue key
Includes bibliographical references

  link to old catalogue

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