Catalogue


The Cutter incident [electronic resource] : how America's first polio vaccine led to the growing vaccine crisis /
Paul A. Offit.
imprint
New Haven : Yale University Press, c2005.
description
xii, 238 p. : ill., ports. ; 25 cm.
ISBN
0300108648 (cloth : alk. paper), 9780300108644 (cloth : alk. paper)
format(s)
Book
Holdings
More Details
imprint
New Haven : Yale University Press, c2005.
isbn
0300108648 (cloth : alk. paper)
9780300108644 (cloth : alk. paper)
restrictions
Licensed for access by U. of T. users.
catalogue key
12025935
 
Includes bibliographical references (p. 195-227) and index.
A Look Inside
About the Author
Author Affiliation
Paul A. Offit, M.D., is chief of the Division of Infectious Diseases and Henle Professor of Immunologic and Infectious Diseases at the Children's Hospital of Philadelphia. He is also professor of pediatrics at the University of Pennsylvania School of Medicine
Full Text Reviews
Appeared in Publishers Weekly on 2005-09-05:
After a wave of books celebrating the 50th anniversary of Jonas Salk's polio vaccine, Offit's troubling account is the first to focus on a largely forgotten aspect-one with negative repercussions 50 years later. In a nuanced examination of a complex story, Offit, a professor of pediatrics and expert in infectious diseases, relates how Cutter Laboratories, one of several pharmaceutical companies licensed to produce Salk's killed-virus vaccine, shipped many lots of vaccine containing live virus, creating a mini polio epidemic: 40,000 children became ill, 200 were permanently paralyzed, 10 died. Offit carefully examines how Cutter was and was not responsible: tests for detecting live virus at the time were simply not sensitive enough, but Cutter departed from Salk's safe production protocols. And while the company knew there was a problem, it failed to notify the government's oversight agency. Cutter faced costly lawsuits that have resulted, according to Offit, in today's vaccine crisis: shortages (think of last year's flu vaccine) due to pharmaceutical companies' unwillingness to risk testing and producing vaccines and face possible litigation. In another example of the law of unintended consequences, Offit shows how "the Cutter Incident" led Salk's vaccine to be replaced by a less safe one: Sabin's live-virus vaccine. (Oct.) (c) Copyright PWxyz, LLC. All rights reserved
Appeared in Choice on 2006-01-01:
The case of Gottsdanker v. Cutter Laboratories, a 1958 negligence case, has had strong implications for the vaccine shortages of recent years and is likely to impact the course of pharmaceutical availability for many years. Cutter was one of the first five companies to be licensed to manufacture the Salk polio vaccine. Following the protocols of the time, the company produced several batches of vaccine that inadvertently contained live virus. Many children were infected with polio when they were vaccinated; Anne Elizabeth Gottsdanker was one of them. The verdict in the case set new ground, holding that even though Cutter Laboratories was not negligent, it was still liable for damages. "By no longer requiring personal injury lawyers to prove negligence, companies were more easily held liable for products that are harmful. They were also more easily held liable for products that were safe." Offit (Children's Hospital of Philadelphia) also carefully analyzes the pre- and post-Cutter eras in vaccines. This extraordinarily fine, well-researched, and beautifully written book deserves the widest possible readership. More physicians should write this well. ^BSumming Up: Highly recommended. All levels. I. Richman emeritus, Pennsylvania State University, Harrisburg Campus
Reviews
Review Quotes
"What is causing the shortage of desperately needed vaccines to combat pneumonia, tetanus, chicken pox, measles, mumps and influenza? Why is an effective vaccine for Lyme disease no longer on the market? And what are the consequences for our children? Dr. Paul Offit confronts these vital questions in The Cutter Incident, a brilliant piece of writing about a medical tragedy, exactly fifty years ago, that revolutionized the development and testing of vaccines in the United States, while forever changing the legal culture that had once kept punitive lawsuits under control. Offit�s remarkable book is certain to become a fixture in the increasingly angry battle over the impact of medical liability on the effective treatment of disease."�David M. Oshinsky, author of Polio: An American Story
"What is causing the shortage of desperately needed vaccines to combat pneumonia, tetanus, chicken pox, measles, mumps and influenza? Why is an effective vaccine for Lyme disease no longer on the market? And what are the consequences for our children? Dr. Paul Offit confronts these vital questions in The Cutter Incident , a brilliant piece of writing about a medical tragedy, exactly fifty years ago, that revolutionized the development and testing of vaccines in the United States, while forever changing the legal culture that had once kept punitive lawsuits under control. Offit's remarkable book is certain to become a fixture in the increasingly angry battle over the impact of medical liability on the effective treatment of disease."David M. Oshinsky, author of Polio: An American Story
"What is causing the shortage of desperately needed vaccines to combat pneumonia, tetanus, chicken pox, measles, mumps and influenza? Why is an effective vaccine for Lyme disease no longer on the market? And what are the consequences for our children? Dr. Paul Offit confronts these vital questions inThe Cutter Incident, a brilliant piece of writing about a medical tragedy, exactly fifty years ago, that revolutionized the development and testing of vaccines in the United States, while forever changing the legal culture that had once kept punitive lawsuits under control. Offit's remarkable book is certain to become a fixture in the increasingly angry battle over the impact of medical liability on the effective treatment of disease."David M. Oshinsky, author ofPolio: An American Story
"What is causing the shortage of desperately needed vaccines to combat pneumonia, tetanus, chicken pox, measles, mumps and influenza? Why is an effective vaccine for Lyme disease no longer on the market? And what are the consequences for our children? Dr. Paul Offit confronts these vital questions in "The Cutter Incident," a brilliant piece of writing about a medical tragedy, exactly fifty years ago, that revolutionized the development and testing of vaccines in the United States, while forever changing the legal culture that had once kept punitive lawsuits under control. Offit's remarkable book is certain to become a fixture in the increasingly angry battle over the impact of medical liability on the effective treatment of disease."--David M. Oshinsky, author of "Polio: An American Story"
�This book not only brings to life the main actors involved, it also demonstrates how this incident created legal precedents that forever changed product liability laws.��Roland Sutter,World Health Organization
"Well written and easily understood, yet balanced with enough technical detail for medical professionals to read informatively cover to cover."
�Well written and easily understood, yet balanced with enough technical detail for medical professionals to read informatively cover to cover.�
"What is causing the shortage of desperately needed vaccines to combat pneumoniaa, tetanus, chicken pox, measles, mumps and influenza? Why is an effective vaccine for Lyme disease no longer on the market? And what are the consequences for our children? Dr. Paul Offit confronts these vital questions in The Cutter Incident, a brilliant piece of writing about a medical tragedy, exactly fifty years ago, that revolutionized the development and testing of vaccines in the United States, while forever changing the legal culture that had once kept punitive lawsuits under control. Ofitt's remarkable book is certain to become a fixture in the increasingly angry battle over the impact of medical liability on the effective treatment of disease."-David M. Oshinsky, author of Polio: An American Story
" What is causing the shortage of desperately needed vaccines to combat pneumonia, tetanus, chicken pox, measles, mumps and influenza? Why is an effective vaccine for Lyme disease no longer on the market? And what are the consequences for our children? Dr. Paul Offit confronts these vital questions in The Cutter Incident , a brilliant piece of writing about a medical tragedy, exactly fifty years ago, that revolutionized the development and testing of vaccines in the United States, while forever changing the legal culture that had once kept punitive lawsuits under control. Offit's remarkable book is certain to become a fixture in the increasingly angry battle over the impact of medical liability on the effective treatment of disease. "-David M. Oshinsky, author of Polio: An American Story
"One of the best overviews of vaccines from the vantage of events associated with vaccine safety during an earlier era that I have ever read."Maurice Hilleman, Merck Institute for Vaccinology
"One of the best overviews of vaccines from the vantage of events associated with vaccine safety during an earlier era that I have ever read."--Maurice Hilleman, Merck Institute for Vaccinology
"One of the best overviews of vaccines from the vantage of events associated with vaccine safety during an earlier era that I have ever read."�Maurice Hilleman, Merck Institute for Vaccinology
"This book not only brings to life the main actors involved, it also demonstrates how this incident created legal precedents that forever changed product liability laws."-Roland Sutter,World Health Organization
"This book not only brings to life the main actors involved, it also demonstrates how this incident created legal precedents that forever changed product liability laws."Roland Sutter,World Health Organization
"This book not only brings to life the main actors involved, it also demonstrates how this incident created legal precedents that forever changed product liability laws."--Roland Sutter, World Health Organization
"One of the best overviews of vaccines from the vantage of events associated with vaccine safety during an earlier era that I have ever read."-Maurice Hilleman, Merck Institute for Vaccinology
�Dr. Offit brings us into the entangled world of medicine and law. Readers will have a better understanding of the impact that legal suits have on the vaccine industry, investment, and decisions not to pursue lifesaving vaccines because of liability issues.��Dean Mason, President and CEO, Sabine Vaccine Institute
"Dr. Offit brings us into the entangled world of medicine and law. Readers will have a better understanding of the impact that legal suits have on the vaccine industry, investment, and decisions not to pursue lifesaving vaccines because of liability issues."--Dean Mason, President and CEO, Sabine Vaccine Institute
"Dr. Offit brings us into the entangled world of medicine and law. Readers will have a better understanding of the impact that legal suits have on the vaccine industry, investment, and decisions not to pursue lifesaving vaccines because of liability issues."-Dean Mason, President and CEO, Sabine Vaccine Institute
"Dr. Offit brings us into the entangled world of medicine and law. Readers will have a better understanding of the impact that legal suits have on the vaccine industry, investment, and decisions not to pursue lifesaving vaccines because of liability issues."Dean Mason, President and CEO, Sabine Vaccine Institute
This item was reviewed in:
Publishers Weekly, September 2005
Booklist, October 2005
Choice, January 2006
To find out how to look for other reviews, please see our guides to finding book reviews in the Sciences or Social Sciences and Humanities.
Summaries
Short Annotation
Vaccines have saved more lives than any other single medical advance.
Main Description
Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture.Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation's relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury's verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.
Long Description
Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture. Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation's relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury's verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.
Bowker Data Service Summary
Paul Offit recounts a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, that has led many pharmaceutical companies to abandon vaccine manufacture.
Table of Contents
Prologuep. xi
Introductionp. 1
Little White Coffinsp. 4
Back to the Drawing Boardp. 19
The Grand Experimentp. 44
How Does It Feel to Be a Killer of Children?p. 58
A Man-Made Polio Epidemicp. 83
What Went Wrong at Cutter Laboratoriesp. 105
Cutter in Courtp. 132
Cigars, Parasites, and Human Toesp. 154
Death for the Lambsp. 178
Epiloguep. 192
Notesp. 195
Selected Bibliographyp. 225
Acknowledgmentsp. 229
Indexp. 231
Table of Contents provided by Ingram. All Rights Reserved.

This information is provided by a service that aggregates data from review sources and other sources that are often consulted by libraries, and readers. The University does not edit this information and merely includes it as a convenience for users. It does not warrant that reviews are accurate. As with any review users should approach reviews critically and where deemed necessary should consult multiple review sources. Any concerns or questions about particular reviews should be directed to the reviewer and/or publisher.

  link to old catalogue

Report a problem