Biophysics of infection /
Mark C. Leake, editor.
Switzerland : Springer, [2016], c2016
ix, 362 p. : ill. (some col.) ; 24 cm.
3319321870, 3319321897, 9783319321875, 9783319321899
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Switzerland : Springer, [2016], c2016
contents note
The biophysics of infection / Mark C. Leake -- Single-molecule observation of DNA replication repair pathways in E. coli / Adam J.M. Wollman, Aisha H. Syeda, Peter McGlynn and Mark C. Leake -- Investigating the swimming of microbial pathogens using digital holography / K.L. Thornton, R.C. Findlay, P.B. Walrad and L.G. Wilson -- What is the 'minimum inhibitory concentration' (mic) of pexiganan acting on escherichia coli? -- a cautionary case study / Alys K. Jepson, Jana Schwarz-Linek, Lloyd Ryan, Maxim G. Ryadnov and Wilson C.K. Poon -- Evolution of drug resistance in bacteria / B. Waclaw -- Using biophysics to monitor the essential protonmotive force in bacteria / Mei-Ting Chen and Chien-Jung Lo -- The Type I restriction enzymes as barriers to horizontal gene transfer: determination of the DNA target sequences recognised by livestock-associated methicillin-resistant Staphylococcus aureus clonal complexes 133/ST771 and 398 / Kai Chen, Augoustinos S. Stephanou, Gareth A. Roberts, John H. White, Laurie P. Cooper, Patrick J. Houston, Jodi A. Lindsay and David T.F. Dryden -- Biomechanical analysis of infectious biofilms / David Head -- Designing a single-molecule biophysics tool for characterising DNA damage for techniques that kill infectious pathogens through DNA damage effects / Helen Miller, Adam J.M. Wollman and Mark C. Leake -- Bacterial surfaces: front lines in host-pathogen interaction / Jane E. King and Ian S. Roberts -- Biophysical approaches to bacterial gene regulation by riboswitches / Cibran Perez-Gonzalez, Jonathan P. Grondin, Daniel A. Lafontaine and J. Carlos Penedo -- Bugs on a slippery plane / Dmitri O. Pushkin and Martin A. Bees -- Transcription regulation and membrane stress management in enterobacterial pathogens / Nan Zhang, Goran Jovanovic, Christopher McDonald, Oscar Ces, Xiaodong Zhang and Martin Buck -- How biophysics may help us understand the flagellar motor of bacteria which cause infections / Matthew A.B. Baker -- Mechanics of bacterial cells and initial surface colonization / Sebastian Aguayo and Laurent Bozec -- Neutron reflectivity as a tool for physics-based studies of model bacterial membranes / Robert D. Barker, Laura E. McKinley and Simon Titmuss -- Mechanisms of Salmonella typhi host restriction / Stefania Spanò -- Insights into biological complexity from simple foundations / L. Albergante, D. Liu, S. Palmer and T.J. Newman -- Force spectroscopy in studying infection / Zhaokun Zhou and Mark C. Leake -- Imaging immunity in lymph nodes: past, present and future / James Butler, Amy Sawtell, Simon Jarrett, Jason Cosgrove, Roger Leigh, Jon Timmis and Mark Coles -- Novel approaches to manipulating bacterial pathogen biofilms: whole-systems design philosophy and steering microbial evolution / Alexandra S. Penn -- Index.
"This book describes modern biophysical techniques that enable us to understand and examine dynamic processes of infection at the molecular level. Cutting-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such as single-molecule observation of DNA replication repair pathways in E. coli; evolution of drug resistance in bacteria; restriction enzymes as barriers to horizontal gene transfer in Staphylococcus aureus; infectious and bacterial pathogen biofilms; killing infectious pathogens through DNA damage; bacterial surfaces in host-pathogen interactions; bacterial gene regulation by riboswitches; transcription regulation in enterobacterial pathogens; the bacterial flagellar motor; initial surface colonization by bacteria; Salmonella Typhi host restrictions; as well as monitoring proton motive force in bacteria; microbial pathogens using digital holography; mathematical modelling of microbial pathogen motility; neutron reflectivity in studying bacterial membranes; force spectroscopy in studying infection and 4D multi-photon imaging to investigate immune responses. The focus is on the development and application of complex techniques and protocols at the interface of life sciences and physics, which increase the physiological relevance of biophysical investigations"--Publisher's description.
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Includes bibliographical references and index.

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