Precision Molecular Pathology of Breast Cancer [electronic resource] /
edited by Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil.
1st ed. 2015.
New York, NY : Springer New York : Imprint: Springer, 2015.
X, 338 p. 29 illus., 28 illus. in color. online resource.
9781493928859 (print), 9781493928866
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New York, NY : Springer New York : Imprint: Springer, 2015.
9781493928859 (print)
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Licensed for access by U. of T. users.
contents note
Molecular basis of breast cancer imaging -- Familial Breast Cancer and Genetic Predisposition in Breast Cancer -- Modelling the Molecular Pathology of Breast Cancer Initiation -- Molecular Pathology of Precancerous Lesions of the Breast -- Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted Therapy -- Molecular Pathology of Pre-Invasive Ductal Carcinoma. -Molecular Pathology of Lobular Carcinoma Ali Sakhdari, Lloyd Hutchinson, Ediz Cosar -- Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic Implications -- Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy -- Molecular Classification of Breast Cancer -- Triple Negative Breast Cancer: Subtypes with Clinical Implications -- Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast Cancer -- Role of MicroRNAs in Breast Cancer -- Molecular Pathology of Fibroepithelial Neoplasms of the Breast -- Molecular Features of Mesenchymal Tumors of the Breast -- Molecular Pathology of Breast Cancer Metastasis -- The molecular pathology of chemoresistance during the therapeutic response in breast cancer -- The Molecular Pathology of Male Breast Cancer -- Specimens for Molecular Testing in Breast Cancer.
This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2.   Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.
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