Cham : Springer International Publishing : Imprint: Springer, 2016.
Licensed for access by U. of T. users.
Epidemiology and Management: Epidemiology -- Emerging Role of HPV -- Management of Oral Cancer. Development and Biomarkers: Molecular Progression and Signaling -- Stem Cells and Tumor Development -- Prognostic/Predictive Biomarkers -- EIF4e as Biomarker and Target. Breaking Developments and New Drug Discovery: Current Clinical Trials -- Emerging Drug Targets -- Targeting the UPR -- Targeting Meditators of Coagulation -- Resveratrol Pre-Sensitizing -- Academic High Throughput Drug Discovery.
This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of human papillomavirus in oral cancer and explains the surgical, chemotherapy, and radiation approaches to treatment. Aspects such as molecular progression and signaling, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation. Recent decades have witnessed a significant increase in the number of deaths worldwide from cancers of the oral cavity, pharynx, and oropharynx. Targeting Oral Cancer will be an excellent resource for practitioners and researchers and will hopefully assist in the urgent quest to improve screening and prevention, diagnosis, and treatment approaches.